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Scientists uncover role of Fanconi anemia genes.
2003 JUN 3 - (NewsRx.com & NewsRx.net) -- Scientists at the Johns Hopkins Kimmel Cancer Center have identified three genes, long linked to a rare inherited disease known as Fanconi anemia (FA), that now appear to play a role in many cases of pancreatic cancer.
All of the genes identified, when functioning normally, are part of the DNA repair process. The work is reported in Cancer Research.
"What we think we have is a new genetic cause of some cases, approximately 10% or more, of pancreatic cancers, one of the most lethal forms of cancer," according to Scott Kern, MD, professor of oncology and pathology at the Sidney Kimmel Comprehensive Cancer Center at Johns …
- Johns Hopkins Scientists Uncover Role of Fanconi's Anemia Genes in Pancreatic...
- News wire article from: Ascribe Higher Education News Service May 14, 2003 700+ words
...selection and dose. Kern says preliminary...in patients with FA gene mutations. He is...copy of at least one FA gene. "Our findings...be so random," Kern says. "It is likely...loss of only one FA gene also was disease...of cancer," says Kern. Pancreatic cancer...
- Fanconi anemia gene mutations are present in young-onset pancreatic cancer.
- Newspaper article from: Cancer Gene Therapy Week July 21, 2003 700+ words
...FA when two allelic mutations are inherited. "BRCA2 is an FA gene and additionally conveys an inherited risk for breast, ovarian...2585-2588). For additional information, contact S.E. Kern, Johns Hopkins University, Sidney Kimmel Comprehensive Cancer...
Source: HighBeam Research, Scientists uncover role of Fanconi anemia genes.
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