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Tumor-derived TGF-beta reduces efficacy of dendritic cell/tumor fusion vaccine.
2003 MAY 21 - (NewsRx.com & NewsRx.net) -- Tumor-derived TGF-beta reduced the efficacy of a dendritic cell/tumor fusion vaccine.
According to a study from the United States, "Dendritic cell (DC)-based antitumor vaccine is a novel cancer immunotherapy that is promising for reducing cancer-related mortality. However, results from early clinical trials were suboptimal. A possible explanation is that many tumors secrete immunosuppressive factors such as TGF-beta, which may hamper host immune response to DC vaccine."
"In this study, we demonstrated that TGF-beta produced by tumors significantly reduced the potency of DC/tumor fusion vaccines," reported John Y. Kao and colleagues at the University of Michigan. "TGF-beta-secreting (CT26-TGF-beta) stable mouse colon cancer cell lines were generated using a retroviral vector expressing TGF-beta. A non-TGF-beta-secreting (CT26-neo) cell line was generated using an empty retroviral vector. The efficacies of DC/tumor fusion vaccines were assessed in vitro and in vivo."
"DC/CT26-TGF-beta fusion cells failed to induce a strong T cell proliferative response in vitro, mainly due to the effect of TGF-beta on T cell responsiveness rather than DC stimulatory capability," stated Kao and his associates. "Animals vaccinated with DC/CT26-TGF-beta fusion vaccine had lower tumor-specific CTL activity and had significantly lower ...
- Runx3 regulates mouse TGF-beta-mediated dendritic cell activity.
- Newspaper article from: Drug Week June 4, 2004 700+ words
...net) -- Runx3 regulates TGF-beta-mediated dendritic cell activity in mice. According...mediates their response to TGF-beta," according to...Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence...
- Transforming growth factor beta inhibits action of dendritic cell vaccines.
- Newspaper article from: Vaccine Weekly June 18, 2003 700+ words
...antitumor activity of dendritic cell vaccines. "Dendritic cell (DC)-based vaccines...growth factor beta (TGF-beta), a cytokine...neutralization of TGF-beta in tumor...antitumor activity of dendritic cell vaccines. Cancer...
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- Newspaper article from: Immunotherapy Weekly June 26, 2002 700+ words
...against HIV infection. "Dendritic cell-specific ICAM-3...a monocyte-derived dendritic cell (MDDC)-specific lectin which participates in dendritic cell (DC) migration and...negatively regulated by IFN, TGF-beta, and anti...
- CD25+ CD4 cells inhibit dendritic cell maturation and function.
- Newspaper article from: Biotech Week June 9, 2004 700+ words
...despite prestimulation with CD40 ligand," the report indicated. "This effect was marginally reverted by neutralizing Abs to TGF-beta. There was an increased IL-10 secretion and reduced expression of costimulatory molecules in DC." "Thus, in addition...
- Research Suggests Tumors May Actively Suppress Dendritic Cell Function.
- Newspaper article from: Immunotherapy Weekly July 13, 1998 700+ words
...conference. "Alternatively, tumors may actively suppress DC function through the production of mediators such as IL-10 and TGF(beta)." The researchers suggested the possibility that DC activation is occurring after migration out of the tumors...
- Aastrom Biosciences Executes Evalaution Agreements With Leading German...
- Press release article from: PR Newswire April 19, 2001 700+ words
- DC-I Dendritic Cell Product Advances Toward U.S...European evaluation of its DC-I dendritic cell product for use in cancer vaccines...School teaching hospital. "As dendritic cell-based vaccines are being broadly...
- Aastrom Biosciences Begins Site Testing New Dendritic Cell Vaccine Product for...
- Press release article from: PR Newswire March 15, 2001 700+ words
...site evaluation of Aastrom's DC-I dendritic cell product for use in vaccines to treat...external phase of a plan to make its dendritic cell product broadly available for dendritic cell-based cancer vaccines. Once the beta...
- Dendritic cell-based glioma immunotherapy reviewed.
- Newspaper article from: Biotech Week August 20, 2003 700+ words
...amp; NewsRx.net) -- A review of dendritic cell-based glioma immunotherapy has been...Niigata University. "Therefore, dendritic cell-based immunotherapy could be a new...therapy." "A literature review of dendritic cell-based glioma immunotherapy was used...