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Using CTLA-4 to target APCs could boost immunogenicity of HIV-1 vaccines.
2003 MAY 21 - (NewsRx.com & NewsRx.net) -- Using CTLA-4 to target antigen-presenting cells could boost immunogenicity of HIV-1 vaccines, suggest Aaron Diamond AIDS Research Center scientists.
Pointing to study results indicating weak immunogenicity of DNA-based vaccines in humans, W. Zhang, David Ho, and colleagues tried strengthening the immune response to "a DNA vaccine by targeting antigen-presenting cells (APC) through fusion of SIV gag with the extracellular domain of mouse CTLA-4."
They described their work in a poster presentation at the 10th conference on Retroviruses and Opportunistic Infections held in Boston, Massachusetts, in 2003.
"We constructed a DNA vaccine encoding a fusion gene, combining the ecto-domain of mouse CTLA-4 with a synthetic, 'optimized' SIV gag. As a control, we made a similar construct, CTLA4mut-gag, wherein the B7-binding domain in CTLA-4 was mutated," said Zhang and colleagues.
The mice received various doses of the vaccine, administered intramuscularly, and various times.
"Cell-mediated immune responses were assessed by studying splenocytes in antigen-specific IFN-gamma ELISpot assays, and humoral responses were measured by ELISA," they ...
- Using CTLA-4 to target APCs could boost immunogenicity of HIV-1 vaccines.
- Newspaper article from: AIDS Vaccine Week May 19, 2003 700+ words
...through fusion of SIV gag with the extracellular domain of mouse CTLA-4." They described...fusion of wild-type CTLA-4 to gag significantly enhanced...immunologic studies showed that CTLA-4-gag, but not the mutant form...
- Stem cell CTLA-4 may be therapeutic target.
- Newspaper article from: Immunotherapy Weekly February 26, 2003 700+ words
...cytotoxic T-lymphocyte antigen-4 (CTLA-4) molecule in human normal and neoplastic...analysis carried out with a panel of anti-CTLA-4 human single-chain fragment of variable domain (scFv) antibodies revealed that CTLA-4 was not expressed on the surface...
- Stem cell CTLA-4 may be therapeutic target.(Brief Article)
- Magazine article from: Stem Cell Week February 24, 2003 700+ words
...cytotoxic T-lymphocyte antigen-4 (CTLA-4) molecule in human normal and neoplastic...analysis carried out with a panel of anti-CTLA-4 human single-chain fragment of variable domain (scFv) antibodies revealed that CTLA-4 was not expressed on the surface...
- Stem cell CTLA-4 may be therapeutic target.(cytotoxic T-lymphocyte antigen-4 in...
- Newspaper article from: Cancer Weekly February 25, 2003 700+ words
...cytotoxic T-lymphocyte antigen-4 (CTLA-4) molecule in human normal and neoplastic...analysis carried out with a panel of anti-CTLA-4 human single-chain fragment of variable domain (scFv) antibodies revealed that CTLA-4 was not expressed on the surface...
- Tyrosine-mediated inhibitory signals contribute to CTLA-4 function.
- Newspaper article from: Blood Weekly June 3, 2004 700+ words
...Tyrosine-mediated inhibitory signals contribute to CTLA-4 function. "The ability of CTLA-4 to inhibit T cell activation may be either...critical tyrosine at position 201 (Y201) within the CTLA-4 cytoplasmic domain. By binding to the clathrin...
- Inhibition of T cell activation and autoimmune diabetes using a B cell...
- Magazine article from: Journal of Clinical Investigation Fife, Brian T. Griffin, Matthew D. Abbas, Abul K. Locksley, Richard M. Bluestone, Jeffrey A. August 1, 2006 700+ words
CTL-associated antigen 4 (CTLA-4) engagement negatively regulates T cell activation and...difficult to explore the biology of selective engagement of CTLA-4 in vivo because CTLA-4 shares its ligands, B7-1 and B7-2, with CD28...
- Medarex Signs Development Agreement with Gilead for Anti-CTLA-4 Therapeutics.
- Press release article from: PR Newswire August 31, 1999 700+ words
CTLA-4 Blockade May Provide Novel Treatment for...Sciences, Inc. (Nasdaq: GILD) to the CTLA-4 Blockade intellectual property rights...high-affinity antibodies that inhibit CTLA-4, an immune system modulator. Medarex...
- CTLA-4 blockage increases resistance to infection with Trypanosoma cruzi.
- Newspaper article from: Biotech Week June 23, 2004 700+ words
...NewsRx.com & NewsRx.net) -- CTLA-4 blockage increases resistance to infection...studies have revealed an important role for CTLA-4 as a negative regulator of T cell activation...study, we evaluated the importance of CTLA-4 to the immune response against the...
