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Vaccines for acute lymphoblastic leukemia available.

Vaccine Weekly

| May 21, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 MAY 21 - (NewsRx.com & NewsRx.net) -- Vaccines are available for the treatment of acute lymphoblastic leukemia.

"Acute lymphoblastic leukemia (ALL) represents the most frequent malignant disease in childhood and adolescence and offers a good prognosis with approximately 80% survival in first remission after polychemotherapy and radiotherapy. In addition, many children with relapsed or refractory ALL will still be cured by allogeneic hematopoietic stem cell transplantation (alloHSCT). However, therapeutic options are limited with a very poor prognosis in case of another relapse after alloHSCT," scientists in Germany report.

"Here, immunotherapy strategies offer a promising alternative to another chemotherapy or second alloHSCT, which are mainly palliative and accompanied by high morbidity and mortality," reported Christof Maria Kramm and colleagues at Heinrich-Heine University in Dusseldorf, Germany. "Immunotherapy strategies aim at an improvement of the graft-versus-leukemia (GvL) effect. The therapeutic GvL effect is usually associated with graft-versus-host disease (GvHD).

"The definition of patient subgroups with an increased risk ...

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Source: HighBeam Research, Vaccines for acute lymphoblastic leukemia available.

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