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Novel bacillus Calmette-Guerin-MUC1-based breast cancer vaccine developed.
2003 MAY 21 - (NewsRx.com & NewsRx.net) -- A novel bacillus Calmette-Guerin-MUC1-based breast cancer vaccine has been developed and tested.
"Due to the high incidence of breast cancer and associated mortality rate, the development of an effective vaccine may be beneficial for the prevention or adjuvant treatment of this malignancy. We have constructed a novel breast cancer vaccine, Bacillus Calmette-Guerin (BCG)-hIL2MUC1, that consists of BCG and expresses a truncated form of MUC1 and human interleukin (IL)-2. In vitro analysis of the BCG-hIL2MUC1 construct confirmed co-expression of MUC1 and human IL-2," scientists in the United States report.
"The ability of BCG-hIL2MUC1 to inhibit breast cancer growth was evaluated in hu-PBL-SCID mice (severe combined immunodeficient mice reconstituted with 50 x 10[superscript]6 human peripheral blood lymphocytes) that received three biweekly injections of BCG-hIL2MUC1 (0.5 colony-forming unit)," wrote Maureen A. Chung and coauthors at Brown University the University of Iowa and the University of California-Los Angeles.
They continued, "Control animals received PBS, MUC1 peptide (100 microgram), or empty vector BCG-261 (0.5 colony-forming unit) vaccination. After immunization, hu-PBL-SCID mice (n=8 in each group) were xenografted with 4 x 10[superscript]6 ZR75-1 human breast cancer cells. Whereas mice receiving the control vaccines developed a tumor, only 87% of BCG-hIL2MUC1-immunized animals developed a palpable tumor with a slower rate of ...
- NY-ESO-1 shows promise as antigen for breast cancer vaccine development.
- Newspaper article from: Cancer Vaccine Week May 10, 2004 700+ words
...19106-4404, USA. The information in this article comes under the major subject areas of Breast Cancer Vaccine, Breast Cancer Therapy, Cancer Vaccine, Vaccine Development, Immunology, Immunotherapy, Oncology, Women's Health, and Proteomics...
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...that could help 25 percent of women with breast cancer is looking good in early tests. The three...immunologist Dana Leach said at the Third European Breast Cancer Conference last week. No breast cancer vaccine has been approved for human therapy, and...
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...trials for its CeaVac(TM) cancer vaccine in colorectal cancer, and its TriAb(TM) cancer vaccine in breast cancer. Both studies are randomized...CeaVac(TM) is the first cancer vaccine to consistently generate immune...
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...trials for its CeaVac(TM) cancer vaccine in colorectal cancer, and its TriAb(TM) cancer vaccine in breast cancer. Both studies are randomized...CeaVac(TM) is the first cancer vaccine to consistently generate immune...
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...vaccine to prevent breast cancer may be a step closer...Annual San Antonio Breast Cancer Symposium. George Peoples, MD, of the Cancer Vaccine Development Laboratory...commonly overexpressed in breast cancer cells. Peoples and...
- igeneon Initiates Further Pivotal Phase III Clinical Trials With IGN101 Cancer...
- Press release article from: PR Newswire November 11, 2003 700+ words
...additional pivotal trials with its cancer vaccine candidate IGN101. The first...Phase III study in adjuvant breast cancer, which will be conducted in...the first pivotal trial with a breast cancer vaccine in the adjuvant setting (i...
- Biomira shows statistically significant improvement in survival in breast...
- Press release article from: Business Wire December 7, 1995 700+ words
...vaccine, in patients with metastatic breast cancer. The meeting "Novel Vaccine Strategies...Tn (STn), found on the surface of breast cancer cells, than was observed with those...for women who suffer from metastatic breast cancer. Biomira is a biotechnology company...