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Vaccination strategies for Alzheimer's disease reviewed.
2003 MAY 21 - (NewsRx.com & NewsRx.net) -- Researchers have published a recent review of vaccine approaches to the treatment of Alzheimer disease.
According to recent research published in the journal Lancet Neurology, "Recent studies in murine models of Alzheimer's disease (AD) have found that active immunization with amyloid-beta peptide (A-beta) or passive immunization with A-beta antibodies can lessen the severity of A-beta-induced neuritic plaque pathology through the activation of microglia. These antibodies can be detected in the serum and CSF. Whether they slow down or speed up the development and progression of AD has not been determined."
"Furthermore, the conditions that induce formation of such antibodies are unknown, or how specific they are to AD," said Richard C. Dodel at Friedrich-Wilhelms-University in Bonn and colleagues at Ludwig-Maximilian University in Germany and Indiana University in the United States. "However, the evidence suggests at least a potential beneficial role for some features of neuroinflammation in AD.
"A clinical phase II study of an active immunization approach with AN1792 was started in 2001, but was recently suspended ...
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Source: HighBeam Research, Vaccination strategies for Alzheimer's disease reviewed.