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pH-responsive polymers used for intracellular delivery of biomolecular drugs.
2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Bio-inspired pH-responsive polymers have been developed for the intracellular delivery of biomolecular drugs.
"The biotechnology and pharmaceutical industries have developed a wide variety of potential therapeutics based on the molecules of biology: DNA, RNA, and proteins. While these therapeutics have tremendous potential, effectively formulating and delivering them have also been a widely recognized challenge," scientists in the United States report.
"A variety of viruses and toxins have evolved multi-functional biomolecules to solve this problem by directing cellular uptake and enhancing biomolecular transport to the cytoplasm from the low pH endosomal compartment, said Niren Murthy and colleagues at the University Washington in Seattle. "In the study reported here, we have designed and synthesized bio-inspired, pH-responsive polymeric carriers, which we call 'encrypted polymers' that mimic the multi-functional design of biology.
"These encrypted polymers target and direct cellular uptake, as well as enhance cytosolic delivery by ...
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Source: HighBeam Research, pH-responsive polymers used for intracellular delivery of...