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Model provides insights into antibody dynamics in childhood diseases.
2003 MAY 14 - (NewsRx.com & NewsRx.net) -- A generalized model is providing insights into the antibody dynamics in childhood diseases such as measles.
"The introduction of vaccination against acute diseases such as measles induced a dramatic decline in the prevalence of the disease, and a more gradual rise in the proportion of the population whose immunity is derived solely from vaccination. These two factors combine to constitute an important shift in the dynamics of immunity, especially in highly vaccinated populations," scientists in England report.
"We develop a general model to describe both loss of immunity in the absence of disease, and boosting of immunity corresponding to subclinical infection in individuals whose immunity has waned," said Katie Glass and B. T. Grenfell at the University of Cambridge. "We consider the interaction between infection and immunity and identify the key parameters that determine the eradication threshold. We explore the dynamics in the years following the introduction of vaccination using a stochastic version of the model, ...
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Source: HighBeam Research, Model provides insights into antibody dynamics in childhood diseases.