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Meningococcal conjugate vaccine more effective than polysaccharide vaccine.
2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Meningococcal A/C conjugate (MACC) vaccination induced a higher antigen-specific geometric mean avidity index than did the meningococcal A/C polysaccharide vaccine in two-year-old children.
"Two-year-old children were vaccinated with one dose of meningococcal A/C conjugate (MACC) or meningococcal A/C polysaccharide (MACP) vaccine. Meningococcal serogroup A (MenA)-specific IgG geometric mean avidity indices (GMAIs) increased one month after vaccination with MACC (GMAI, 210; 95% confidence interval [CI], 140-300) and MACP (GMAI, 190; 95% CI, 120-310)," scientists writing in the Journal of Infectious Diseases report.
"One year after vaccination, the GMAI of the MACP-vaccinated cohort decreased to 130 (95% CI 100-170), but a constant GMAI was maintained in the MACC-vaccinated cohort (210; 95% CI, 140-300), despite declining MenA-specific IgG antibody levels," wrote Helen Joseph and colleagues at Withington Hospital in England, Aventis ...
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Source: HighBeam Research, Meningococcal conjugate vaccine more effective than polysaccharide...