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Clinical results reported for heat shock protein-based immunotherapy.
2003 MAY 14 - (NewsRx.com & NewsRx.net) -- A presentation by Mojave Therapeutics, Inc., at The Future of Vaccines Conference in Semmering, Austria, included an update on the company's melanoma clinical trial and results from recent pre-clinical studies showing dramatically increased effectiveness of Javelin, Mojave's lead technology platform.
Mojave Therapeutics, Inc. is developing heat shock protein-based immunotherapies. Brian Barber, PhD, its chief scientific officer and senior vice-president, delivered a talk entitled "Delivering T-cell immunity with heat shock proteins."
In a previously reported study of 27 metastatic melanoma patients (AJCC Stages III and IV), formulations based on the Javelin technology were found to be safe and well-tolerated, and generated specific T-cell responses in 9 of 15 evaluable patients. Seven of the 15 patients have shown specific T-cell responses to tyrosinase antigen. Though this trial was not designed to track clinical outcomes, after 2 years in the study six of the seven patients who had T-cell responses to tyrosinase antigen ...
- Heat shock protein 70 protects against methylcholanthrene-induced...
- Newspaper article from: Vaccine Weekly July 10, 2002 700+ words
...writer - Immunization with heat shock protein 70 prevented...containing members of the heat shock protein 70 (hsp 70...experiments (Immunization with heat shock protein 70 from methylcholanthrene...correlating with in vitro T cell responses, Cancer Immunology and...
- Heat shock protein complex successfully treats subset of malignant melanoma...
- Newspaper article from: Vaccine Weekly January 1, 2003 700+ words
...autologous, tumor-derived heat shock protein gp96-peptide...autologous tumor-derived heat shock protein gp96-peptide...tumor-specific T-cell responses in a significant minority...A vaccine containing heat shock protein gp96-peptide...
- Heat shock protein suicide gene-based tumor vaccine provokes antitumor activity.
- Newspaper article from: Life Science Weekly December 7, 2004 700+ words
...NewsRx.net) -- Heat shock protein suicide gene...presenting cells. Heat shock proteins (HSPs) play...specific CD4+ and CD8+ T-cell responses were induced by Ad...induced by an in vivo heat shock protein-suicide gene...
- Heat shock protein mediates cross-presentation of exogenous HIV antigen.
- Newspaper article from: Biotech Week October 6, 2004 700+ words
...NewsRx.net) -- Heat shock protein mediates cross...Strong CD4+ and CD8+ T cell responses are considered important...of 32 aa complexed to heat shock protein (HSP) gp96...Journal of Immunology (Heat shock protein-mediated cross...
- Behcet disease characteristics may be linked to heat shock protein dysfunction.
- Newspaper article from: Health & Medicine Week December 8, 2003 700+ words
...characteristics may be linked to heat shock protein dysfunction due...activity against them. "Heat shock proteins (HSP) are...alphabeta and gammadelta T-cell responses," researchers in Turkey...Rheumatology (The role of heat shock proteins in Behcet...
- Positive Clinical Data Presented for HspE7 Heat Shock Protein Fusion.(for...
- Newspaper article from: Immunotherapy Weekly August 9, 2000 700+ words
...from the two other presentations at the conference supporting these conclusions include: * HspE7 induces proliferative T-cell responses to HPV 16 E7 peptides in healthy volunteers * Presentation and processing of the HspE7 fusion protein by the immune system...
- Positive Clinical Data Presented for HspE7 Heat Shock Protein Fusion.(Brief...
- Newspaper article from: Virus Weekly August 8, 2000 700+ words
...from the two other presentations at the conference supporting these conclusions include: * HspE7 induces proliferative T-cell responses to HPV 16 E7 peptides in healthy volunteers * Presentation and processing of the HspE7 fusion protein by the immune system...
- Vaccine Candidates (Chlamydia) "Sexually Acquired Reactive Arthritis (SAReA)...
- Newspaper article from: Vaccine Weekly November 2, 1998 700+ words
...College of Rheumatology, held November 8-12, 1998, in San Diego, California, "SAReA patients demonstrate specific T cell responses in the synovial fluid to the triggering organism, Ct. Mechanisms by which T cells and bacterial antigens contribute to...