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CD8+ cells essential for clearance of measles virus infection in rhesus monkeys.

Vaccine Weekly

| May 14, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 MAY 14 - (NewsRx.com & NewsRx.net) -- CD8+ lymphocytes are essential for the control and clearance of measles virus infection in rhesus monkeys.

According to recent research published in the Journal of Virology, "The creation of an improved vaccine for global measles control will require an understanding of the immune mechanisms of measles virus containment. To assess the role of CD8+ cytotoxic T lymphocytes in measles virus clearance, rhesus monkeys were depleted of CD8+ lymphocytes by monoclonal anti-CD8 antibody infusion and challenged with wild-type measles virus."

"The CD8+ lymphocyte-depleted animals exhibited a more extensive rash, higher viral loads at the peak of virus replication, and a longer duration of viremia than did the control antibody-treated animals," reported Sallie R. Permar and collaborators at Harvard University, the Oregon Health and Sciences University, and Johns Hopkins University. "These findings indicate a central role for CD8+ lymphocytes in the ...

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Source: HighBeam Research, CD8+ cells essential for clearance of measles virus infection in...

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