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Ocular and respiratory symptoms attributed to influenza vaccine in Canada.
2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Results from a controlled trial involving adults indicated that ocular and respiratory symptoms were associated with an inactivated split influenza vaccine.
"In 2000, an influenza vaccine was associated with unusual ocular and respiratory symptoms (known as 'oculorespiratory syndrome' [ORS]) that possibly were due to numerous microaggregates of unsplit viruses present in the product. We assessed the potential for an improved vaccine formulation (for use in 2001-2002) to cause ORS and other symptoms in adults, using a double-blind, randomized, crossover study design," scientists in Canada report.
"Symptoms were ascertained 24 hours after 622 doses of vaccine and 626 doses of saline placebo were injected," said David W. Scheifele and fellow members of the Canadian Association for Immunization Research and Evaluation. "The risk of ORS was 6.3% after vaccine injection and 3.4% after placebo injection, which yielded a significant vaccine-attributable risk of 2.9% (95% confidence interval, 0.6-5.2). ORS symptoms were mild. Significant differences in risk after injection of vaccine versus placebo existed for ocular soreness and/or itching ...
- Ocular and respiratory symptoms attributed to influenza vaccine in Canada.
- Newspaper article from: Virus Weekly May 13, 2003 700+ words
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