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CD25 depletion delayed growth of parasitaemia during parasite challenge.
2003 MAY 14 - (NewsRx.com & NewsRx.net) -- According to published research from Japan, CD25 depletion clearly delayed the growth of parasitaemia during parasite challenge, particularly in immunized mice.
"CD4+ T cells co-expressing CD25 (CD4+CD25+ T cells) have been identified as immunoregulatory suppressors modulating autoimmune response," wrote T. T. A. Long and colleagues, Nagasaki University, Institute Tropical Medicine.
"Beside that, autoimmune response was supposed to be associated with malaria infection. Based on these data, we hypothesized that CD4+CD25+ T cells may influence protective immunity to malaria parasites, while suppressing autoimmune response arising throughout the course of malarial infection.
"To test this possibility, we evaluated the kinetics of CD4+CD25+ T cells during malaria infection and investigated the influence of CD25 depletion by anti-mouse CD25 monoclonal antibody (PC61) on the infection, using a mouse model of premunition to Plasmodium berghei NK65 malaria.
"The results showed that, during exacerbation of P. berghei NK65 infection, the proportion of CD4+CD25+ T cells among CD4+ T cells decreased, ...
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Source: HighBeam Research, CD25 depletion delayed growth of parasitaemia during parasite...