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Dogs vaccinated with Ancylostoma caninum exhibit antibody response.
2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Dogs vaccinated with Ancylostoma caninum exhibited a strong antibody response.
"Infection with Ancylostoma caninum, an intestinal hookworm of dogs, can cause debilitating and potentially life-threatening disease. In the current study, protective immunity to hookworm infection was induced in dogs following vaccination with irradiation-attenuated third-stage larvae (L3) with significant reductions in both worm (p
"Vaccination with irradiated L3 and challenge with infective L3 stimulated a dominant antibody response to antigens of less than 20 kDa in an excretory/secretory extract from adult parasites," said P. R. Boag and collaborators at the Victorian Institute of Animal Science and Monash University. "Immuno-screening of an adult A. caninum cDNA library with antisera from the vaccine trial identified a number of clones. The three clones with the strongest immunoreactivity proved to be identical and encoded a peptide with similarity to the N-terminal domain of the tissue ...
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Gardeners and barefoot strollers may be inviting a common canine hookworm to take up residence in their intestines -- unless they take precautions, researchers warn. John Croese of the University of Queensland in Australia and his colleagues recently diagnosed nine cases of human infection with the
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