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Previously unknown epitope stimulates immune response to cytomegalovirus antigen.
2003 MAY 14 - (NewsRx.com & NewsRx.net) -- A previously unknown epitope stimulated an immune response to a cytomegalovirus antigen.
According to recent research from the United States, "Unlike the pp65 protein of human cytomegalovirus (CMV), which has an immunodominant peptide, pp65[subscript]495.503, recognized by human CD8+ cells in the context of HLAA*0201, the fine peptide specificity for CMV IE1 has shown no such immunodominance."
"With the use of transgenic HLA A*0201/Kb and HHD II mice, a selected pool of IE1 peptides, including IE1[subscript]p256-264, IE1[subscript]p297-304, and IE1[subscript]p316-324, were shown to stimulate cytolytic T-lymphocyte lysis in the context of HLA A*0201," reported Ghislaine Gallez-Hawkins and colleagues at the Beckman Research Institute of the City of Hope in California. "Based on an intracellular gamma interferon response, IE1[subscript]p297-304, a previously unrecognized CD8 epitope, ...
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Source: HighBeam Research, Previously unknown epitope stimulates immune response to...