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2003 MAY 14 - (NewsRx.com & NewsRx.net) -- The human immunodeficiency virus may use transcytosis across a tight monolayer of polarized human endometrial cells under pro-inflammatory conditions.
According to recent research from France, "Most cases of human immunodeficiency virus (HIV) infection worldwide occur following sexual contact, implying that the virus may breach the protective epithelial barrier lining the genital tract. HIV infection is known to preferentially occur when the genital epithelial integrity is altered, particularly when epithelial micro-ulcerations occur during heterosexual intercourse or ulcerations appear, due to sexually transmitted infections or else in the context of ectopy of the endocervical mucosa, which may leave the genital tissue. We report that R5-tropic infectious HIV-1 isolates are capable of in vitro transcytosis through a tight and polarized monolayer of human endometrial HEC-1 cells."
"Transcytosis of HIV particles was increased two-fold within a pro-inflammatory micro-environment," reported Marie-Paule Carreno and colleagues at INSERM U430 and ...