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HIV vaccine vectors expressing vaccinia virus IL-15 induce cellular immunity.
2003 MAY 14 - (NewsRx.com & NewsRx.net) -- Co-administration of HIV vaccine vectors with vaccinia viruses expressing IL-15, but not IL-2, induced long-lasting cellular immunity.
"Vaccine efficacy is determined largely by cellular and humoral immunity as well as long-lasting immunological memory. IL-2 and IL-15 were evaluated in vaccinia vectors expressing HIV gp160 for the establishment of an effective vaccine strategy. Both IL-2 and IL-15 in the vaccinia vector induced strong and long-lasting antibody-mediated immunity as well as a short-term cytotoxic T cell response against HIV gp120," scientists in the United States report.
"In addition, IL-15 also supported robust CD8+ T cell-mediated long-term immunity, whereas the CD8+ T cell-mediated immunity induced by IL-2 was short-lived," said SangKon Oh and collaborators at the National Cancer Institute and Johns Hopkins University. "Moreover, we found that the cytokine milieu at the time of priming had surprisingly persistent effects on the character of the memory CD8 T cells long afterward with respect ...
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Source: HighBeam Research, HIV vaccine vectors expressing vaccinia virus IL-15 induce cellular...