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Vaccines prolong survival of colorectal cancer patients.
2003 MAY 14 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A vaccine containing autologous tumor cells and one made with the Newcastle disease virus (NDV) prolonged the survival of patients with colorectal cancer.
"The major treatments of malignant tumors of digestive tract postoperatively are radiotherapy and chemotherapy," said Wei Liang and collaborators at Liaoning Provincal Tumor Research Institute in China. "However, it is very difficult to improve the five-year survival rate. We treated these patients with autologous tumor cell vaccine and NDV vaccine and made a 7-year follow-up survey of postoperative patients with autologous tumor cell vaccine."
The investigators randomly assigned 592 patients with stage I-IV colorectal cancer to undergo either resection only (n=257), resection followed by therapy with the autologous tumor cell vaccine (n=310), or resection followed by therapy with the NDV vaccine (n=25).
Liang and associates reported that the "25 patients treated with NDV immunotherapy were all at stage IV without having resection."
The survival rates at 5, 6, and 7 years for the patients who underwent resection only were 45.6%, 44.8%, and 43.4%, respectively. For those patients receiving vaccine therapy in addition to surgery, survival rates were 66.5%, 60.5%, and 56.5%, respectively. Average survival for the control group vs the vaccine group was 4.2 vs 5.1 years, and median survival was 4.5 years vs more than 7 years. Titers of natural killer cells increased and overall immune function improved in vaccinated patients.
The magnitude of a delayed-type hypersensitivity (DTH) reaction in the vaccinated patients correlated with survival.
"The 5-year survival rate was 80% for ...
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