ELISA tests for IgG/IgM gut flora immunity.

Mechanism of Microflora Immunity

The intestinal tract of the human body contains an extensive microflora system (mucosal barrier) that is colonized by over 400 different bacterial species. Approximately 100 trillion bacteria constitute 1.0-1.5 kg of total body weight. The gut flora contains both beneficial and harmful bacteria. The beneficial bacteria serve various roles like synthesizing vitamins, assisting with digestion and absorption, facilitating protective immune responses, and promoting the synthesis of antibodies. The microflora also plays a role in neutralizing toxins, inhibiting viral cell multiplication in enterocytes, and blocking adherence of harmful bacteria to the mucosa. About 60-70% of our immune system involves the gut-associated lymphatic tissue (GALT).

The development of specific immunological tolerance to orally administered antigens requires the presence of an intact gut flora. An intact gram-negative flora is a prerequisite for the induction of delayed type hypersensitivity (DHT) responses. Secretory IgA immunoglobulins are very significant in protecting our natural microflora, as well as protecting us from pathogenic microbes. Intestinal microorganisms down-regulate…