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The wine derivative resveratrol alters genetic expression in cancer cells.
2003 MAY 8 - (NewsRx.com & NewsRx.net) -- The wine derivative resveratrol alters genetic expression in cancer cells.
"Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural compound found in large quantities, most notably in grapes and red wine, which has been shown to have anti-inflammatory, chemopreventive and antiangiogenic effects. We examined whether resveratrol has any effect on growth and gene expression in the human ovarian cancer PA-1 cells," scientists in South Korea reported.
"We show that resveratrol inhibits cell growth and induces apoptosis in PA-1 human ovarian cancer cells. We also investigated the effect of resveratrol on changes of global gene expression during resveratrol-induced growth inhibition and apoptosis in PA-1 cells using a human cDNA microarray with 7448 sequence-verified clones," wrote S.H. Yang and colleagues, GenomicTree Inc., Microarray Division.
"Out of the 7448 genes screened, 118 genes were founded to be affected in their expression levels by more than twofold after 24 hour treatment with 50 micro M resveratrol."
"Resveratrol treatment of PA-1 cells at the final concentration of 50 micro M for 6, 12, 24 and 48 hours and gene expression patterns were analyzed by microarray. Clustering of the genes modulated more than twofold at 3 of the above times points divided the genes into 2 groups. Within these groups, there were specific subgroups of genes whose expressions were ...
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