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Differential tumor markers can track breast cancer characteristics.
2003 MAY 8 - (NewsRx.com & NewsRx.net) -- Differential tumor markers can track breast cancer characteristics.
According to recent research published in the journal Differentiation, "the multi-step nature of metastasis poses difficulties in both design and interpretation of experiments to unveil the mechanisms causing the process. In order to facilitate such studies, we have previously derived a pair of breast tumor cell lines that originate from the same breast tumor but which have diametrically opposite metastatic capabilities."
"In this system, the monoclonal cell line M-4A4 is metastatic to the lungs of athymic mice, whereas clone NM-2C5 is equally tumorigenic but non-metastatic," wrote D. Agarwal and colleagues, University of California at San Diego, Cancer Center.
"Here, we report that representational difference analysis (RDA) of cDNA obtained from the two clonal populations revealed an increased expression of tyrosinase-related protein-1 (TYRP-1) and the matrix metalloproteinase-8 (MMP-8) genes in the non-metastatic cell line. RNA and protein analyses in cultured cells and in primary xenograft tissues confirmed that the non-metastatic cell line expresses TYRP-1 and MMP-8 at levels that are at least 20-fold higher than the metastatic counterpart," researchers reported.
"Other members of the MMP family (MMP-9 and MMP-2) and the tissue inhibitor of metalloproteinase-2 (TIMP-2) were found to be expressed at similar levels in both populations."
"The effects of MMP-8 and TYRP-1 on in vitro invasion and migration were assessed in cells ...
- BT Syntegra Introduces MMP - the One-Vendor Email Management Solution.
- Press release article from: Business Wire March 29, 2004 700+ words
...Editors/High-Tech Writers SAN DIEGO--(BUSINESS WIRE)--March...Message Management Platform (MMP), believed to be the first...of managing corporate email. MMP is an open software platform...support contracts are over. With MMP, Global 2000 corporations now...
- Synovial MMP-1 quantity is similarly high in several rheumatoid diseases.
- Newspaper article from: Clinical Trials Week March 24, 2003 700+ words
...of similar levels of synovial MMP-1 in patients with familial...disease may be explained by MMP-1 being a marker of cytokine...Rheumatology (Comparison of synovial MMP-1 and TIMP-1 levels in patients...information, contact S. Pay, VA San Diego Healthcare Systems, Sect 111K...
- Patriot Scientific Announces Breakthrough Patent Licensing Agreement with...
- Press release article from: Business Wire March 2, 2006 700+ words
SAN DIEGO, Calif. -- Patriot Scientific...Microprocessor Patent(TM) (MMP) Portfolio. Patriot and The TPL Group are co-owners of the MMP Portfolio, which is being exclusively...Fujitsu and the owners of the MMP Portfolio. In striking this...
- MMP Announces Governance Changes.
- Press release article from: PR Newswire December 3, 2008 700+ words
...MGG's general partner and does not own an interest in MMP. MMP's board of directors will continue to consist of seven...vacancies to be filled over time. Unit purchase rights plan MMP also announced that the board of directors has approved...
- MTI-MMP plays critical role in esophageal squamous cell carcinoma progression.
- Newspaper article from: Cancer Gene Therapy Week July 12, 2004 700+ words
...NewsRx.com & NewsRx.net) -- MTI-MMP plays critical role in esophageal squamous...from Japan, "Matrix metalloproteinase (MMP) is critical for carcinoma progression...the prognostic significance of the major MMP family such as MMP-3, MMP-9, MMP...
- MMP (mixed member proportional) is too much of some good things.
- Magazine article from: Inroads: A Journal of Opinion Weaver, Kent January 1, 1998 700+ words
...and other proponents of the Mixed Member Proportional (MMP) system as used in Germany and New Zealand. But MMP has a fatal flaw: the chances that Canada's political elites will adopt MMP are about the same as the odds that they will adopt the...
- MMP LAUNCHES FREE DAILY INTERNET CURRENT AWARENESS SERVICE
- Press release article from: PR Newswire June 17, 1996 700+ words
...17 /PRNewswire/ -- On-line information specialist MMP of Hove, England, has announced the availability of...is free of charge, can be found at http://www.mmp.co.uk/mmp/ MMP's Internet/Intranet current awareness service...
- MMP PORTFOLIO? PREVAILS AFTER MULTIPLE REEXAMS.
- News wire article from: AsiaPulse News September 17, 2009 700+ words
...details below.) (BW)(CA-ALLIACENSE) MMP Portfolio Prevails After Multiple Reexams...the most widely recognized patent in the MMP Portfolio. The TPL Group has extended its...against multiple validity attacks on the MMP Portfolio perpetrated by numerous electronics...
