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Low interleukin-10 levels associated with metabolic syndrome in obese women.
2003 MAY 8 - (NewsRx.com & NewsRx.net) -- Obese women with abnormally low interleukin-10 levels were significantly more likely to have metabolic syndrome than were similar women with higher IL-10 levels.
According to recent research from Italy, "The potential role of anti-inflammatory cytokines in human obesity is unknown. We tested the hypothesis that low serum IL-10 concentrations associate with the metabolic syndrome in obese women."
"Compared with 50 matched nonobese women, the prevalence of the metabolic syndrome (greater than or equal to3 of the following abnormalities: waist circumference >88 cm; triglycerides >1.69 mmol/L; high density lipoprotein cholesterol <1.29 mmol/L; blood pressure,>130/85 mm Hg; glucose >6.1 mmol/L) was higher in 50 obese women (52% vs 16%; p
"As a group, obese women had higher circulating levels of IL-6, C-reactive protein, and IL-10 than nonobese women. In both obese and nonobese women, IL-10 levels were lower in those with than in women without the metabolic syndrome: obese, 1.3 (0.7/2.1) pg/mL vs 4.5 (4.3/7.4) pg/mL (median and quartiles; p
Esposito and her collaborators concluded, "These results show that circulating levels of the anti-inflammatory cytokine IL-10 are elevated in obese women and that low IL-10 levels are associated with the metabolic syndrome."
Esposito and her coauthors published their study in the Journal of Clinical Endocrinology ...
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