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Tumor markers could guide therapeutic strategies for invasive breast cancer.
2003 MAY 8 - (NewsRx.com & NewsRx.net) -- Tumor markers could guide therapeutic strategies for invasive breast cancer.
"Recent studies have demonstrated cyclooxygenase 2 (COX-2) overexpression in various human malignancies, especially in breast cancer, where COX-2 turned out to be a predictor of poor survival. To evaluate the relation of COX-2 and epithelial cell adhesion molecule (Ep-CAM) overexpression and its prognostic significance, we performed a retrospective study on 212 breast cancer patients with a median follow-up time of 10.5 years," scientists writing in the British Journal of Cancer reported.
"Overexpression of COX-2 in tumor tissue samples was assessed by immunohistochemistry. COX-2 overexpression was found in 48.6% of the tumor samples and was predictive for poor disease-free and overall survival," wrote G. Spizzo and colleagues, University of Innsbruck Hospital, Department of Pathology.
"Univariate analysis revealed a strong correlation between COX-2 and Ep-CAM overexpression (p=0.009). Concurrent COX-2 and Ep-CAM overexpression ...
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