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Biosynthesis of MUC1 mucin is modulated by estradiol and tamoxifen.
2003 MAY 8 - (NewsRx.com & NewsRx.net) -- An in vitro study has shown that "MUC1 biosynthesis in human endometrial adenocarcinoma cells (Ishikawa line) is stimulated by estradiol hormone and inhibited by tamoxifen."
"Polymorphic epithelial mucin MUC1 is expressed by most epithelial cancers, although free natural MUC1 antibodies are present in the circulation of healthy subjects as well as in that of cancer patients. The role of MUC1 mucin molecules in cancer cells of endometrium is not precisely known," wrote A. Paszkiewicz-Gadek and colleagues.
They measured the opposing estrogen and tamoxifen effects on MUC1 synthesis by [C-14]threonine or [H-3]glucosamine incorporation into MUC1 protein.
"Tamoxifen applied in combination with estradiol also inhibited this process, but pre-incubation of cells with estradiol resulted in a decrease in the inhibitory effect of tamoxifen," noted the researchers.
"Electroblotting and reactions with antibodies against MUC1 core protein epitopes confirmed the presence of MUC1 in cell lysates and culture media of Ishikawa cells. Reactions with lectins showed the presence of oligosaccharide structures demonstrating ...
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