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Growth factors regulate endometrial hyperpermeability during early pregnancy.
2003 MAY 8 - (NewsRx.com & NewsRx.net) -- Growth factors regulate endometrial hyperpermeability during early pregnancy.
"Vascular endothelial growth factor (VEGF) and its specific receptors FLT-1 and FLK-1 represent an important ligand-receptor system involved in angiogenesis and permeability. These factors are supposed to be influenced by ovarian steroids involved in developmental changes in female reproductive tissue as oviduct and uterus. The aims of this study were to assess the expression of VEGF and its receptor mRNAs during the early implantation period in porcine endometrium using real-time RT-PCR," scientists writing in the journal Experimental and Clinical Endocrinology & Diabetes reported.
"Furthermore, effects of estradiolbenzoate (EB) and progesterone (P) on endometrium of ovariectomized (ovx) pigs were examined by RT-PCR and immunohistochemistry."
"A complete VEGF system was found in endometrial tissue using RT-PCR detecting the main VEGF isoform 188 aa, FLT-1 and FLK-1. A significant upregulation of the mRNAs of VEGF and its receptors was observed in the endometrium during the peri-implantation when compared with the preimplantation period," reported H. Welter and colleagues, Technical University of Munich, Institute of Physiology.
"Regarding endometrium of non-pregnant ovx-pigs an application of P led to elevated transcript levels of VEGF whereas mRNA-expression was reduced after EB treatment compared to nontreated ovx-animals. When pigs were administrated EB and P simultaneously, a decrease in VEGF mRNA concentration was recorded."
"For FLT-1, none of the ...
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Source: HighBeam Research, Growth factors regulate endometrial hyperpermeability during early...