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Erythromycin and amphotericin B together may elevate Candida's tolerance.
2003 MAY 8 - (NewsRx.com & NewsRx.net) -- "Coadministration of erythromycin and amphotericin B to control bacterial and fungal infections, respectively, may inadvertently lead to an elevation in the tolerance of Candida albicans for [the latter]," report medical mycologists.
"Exposure of the yeast Candida albicans to the macrolide antibiotic erythromycin (C37H67NO13) results in elevated tolerance to the polyene antifungal amphotericin e. Erythromycin displays no fungistatic activity against C. albicans but inhibits the synthesis of cytochromes, particularly cytochrome aa(3)," said P. Geraghty and colleagues, National University of Ireland.
Exposing cells to 10 mg/mL erythromycin reduces aerobic respiration by up to 90% and also severely reduced cellular ergosterol levels, the researchers said.
"Erythromycin inhibits protein biosynthesis in ribosomes (mitoribosomes) located within the mitochondrion of the yeast cell, which results in a disruption of cytochrome biosynthesis with an adverse effect on respiration. The synthesis of ergosterol is oxygen dependent and consequently ergosterol levels are depleted in ...
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Source: HighBeam Research, Erythromycin and amphotericin B together may elevate Candida's...