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Two biomarkers are valuable for predicting women's response to tamoxifen.
2003 MAY 8 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer-A new study of patients with advanced breast cancer has shown that at least two markers are useful for predicting the therapeutic value of tamoxifen.
The multicenter study, which included 160 advanced breast cancer patients, was carried out in the Netherlands. According to Els M.J.J. Berns and colleagues, earlier studies showed that mutations of the TP53 gene or elevated cytosolic levels of the angiogenesis marker vascular endothelial growth factor (VEGF) were prognosticators for outcomes in women who received tamoxifen for advanced breast cancer. Their current study evaluated how predictive the two markers would be when combined.
Each of the patients had estrogen receptor (ER)-positive tumors and were followed for a median of 64 months after beginning therapy, researchers indicated.
"To assess TP53 gene mutation status, the entire open reading frame was sequenced; for VEGF status, an ELISA was used," they noted.
In concordance with data from the earlier studies, each of the markers alone was significantly associated with "short progression-free survival, post-relapse overall survival, and a poor rate of response to tamoxifen," study coauthors said.
Statistical analysis also revealed that a combination of VEGF and TP53 was indicative of poor patient outcomes.
"When the two factors were combined, a significantly decreased odds ratio was seen for ...
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