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Isoliquiritigenin in licorice has estrogenic and antiproliferative activities.
2003 MAY 8 - (NewsRx.com & NewsRx.net) -- At lower levels, licorice root's isoliquiritigenin is an estrogenic agonist and at higher levels it is cytotoxic.
According to a study from Italy, "Licorice root contains chemically diverse compounds that exhibit estrogenic effects in vitro and in vivo. The chalcone isoliquiritigenin (ISL) is a component of licorice extract exhibiting either antitumorigenic activity or estrogen receptor (ER) alpha-dependent growth promoting effects on breast cancer cells.
"In order to contribute to a better understanding of this apparent paradox, we synthesized and ascertained the estrogenic properties of ISL using, as model systems, the hormone-sensitive MCF7 breast cancer cells and the steroid-independent HeLa cells.
"Transfection experiments reveal that ISL is able to transactivate the endogenous ERalpha in MCF7 cells and this is supported by the capability to induce downregulation of ERalpha protein levels and upregulation of pS2 mRNA. Moreover, by using chimeric proteins consisting of the hormone binding domains of ERalpha and ERP fused to the Ga14 DNA binding domain, we have determined that ISL is an estrogenic agonist of both ER isoforms.
"As a biological counterpart, low and intermediate ISL ...
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Source: HighBeam Research, Isoliquiritigenin in licorice has estrogenic and antiproliferative...