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An antisense gene targeting strategy could make breast tumors chemosensitive.
2003 MAY 8 - (NewsRx.com & NewsRx.net) -- An antisense gene targeting strategy could make breast tumors chemosensitive.
"Overexpression of the HER-2 correlates with drug-resistance and a poor prognosis in breast cancer, however the mechanism(s) of HER-2-mediated drug-resistance are unknown. We examined the effects of antisense Bcl-2 and HER-2 oligonucleotides (ODN) to assess the mechanism(s) through which down-regulation of Bcl-2 and HER-2 enhances drug-sensitivity," investigators in Japan reported.
"Using two human breast cancer cell lines, MDA-MB-231 and BT-474, the antitumor effects of a combination of antisense ODN and anticancer drugs, including mitomycin C (MMC), adriamycin (ADM), paclitaxel (TXL), and docetaxel (TXT) was evaluated," wrote K. Tanabe and colleagues, Hiroshima University, Research Institute for Radiation Biology and Medicine.
"The expression of Bcl-2 protein was suppressed by treatment with antisense Bcl-2 ODN in a dose-dependent manner. An enhanced drug-sensitivity to MMC and TXL upon pretreatment with antisense Bcl-2 ODN was observed, with the IC50 values increasing 1.9- and 2.0-fold, respectively."
"Treatment of BT-474 cells with antisense HER-2 at 1.0 microM suppressed HER-2 overexpression by 60.5%. Pretreatment with antisense HER-2 ODN increased the sensitivity of these cells to ADM and TXL 20.8- and 10.8-fold, respectively," said investigators.
"In vivo experiments using a combination of antisense ...
- Senator Kennedy Dedicates New Schepens Eye Research Institute Laboratories,...
- News wire article from: AScribe Medicine News Service Schepens Eye Research Institute March 30, 2005 700+ words
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- Press release article from: PR Newswire December 8, 2003 700+ words
...SCYNEXIS Europe and GeneCare Research Institute Co Ltd in Kamakura, Japan, have...purification services to support GeneCare Research Institute's on-going work in the field...subsequent screening by GeneCare Research Institute. HEOS(TM) will also be used for...
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- Press release article from: PR Newswire June 23, 1989 700+ words
...president of the Merrell Dow Research Institute, will retire on September 1, 1989...be given the title of Merrell Dow Research Institute president emeritus. Temple also...Cincinnati, headquarters of the Research Institute, later this summer. In commenting...
- The Sports Network & Strategic Research Institute Announce New Alliance to...
- Press release article from: PR Newswire December 17, 2002 700+ words
...organizer in the world, Strategic Research Institute, have joined forces to create and...sportsnetwork.com/) and Strategic Research Institute (http://www.srinstitute...found that partner in the Strategic Research Institute." "Strategic Research Institute...
- OPINION: K-State's Biosecurity Research Institute Would Enable Research...
- Press release article from: M2 Presswire December 19, 2008 700+ words
...OPINION: K-State's Biosecurity Research Institute Would Enable Research Programs to Transition...University as well as its Biosecurity Research Institute. The Biosecurity Research Institute in Pat Roberts Hall is a state-of...
- Eisai Research Institute Selects Synthematix's ARTHUR Suite; The innovative...
- Press release article from: PR Newswire March 9, 2004 700+ words
...management systems, today announced Eisai Research Institute has selected Synthematix's ARTHUR...its chemistry operations. "Eisai Research Institute conducted a year-long evaluation...identification at Andover, MA-based Eisai Research Institute. "We are counting on the ARTHUR...
- Agilent Technologies Works Together with The Fifth Electronic Research...
- Press release article from: Business Wire August 22, 2003 700+ words
...collaboration with The Fifth Electronic Research Institute of Ministry of Information Industry...center combines The Fifth Electronic Research Institute's prestige in electronic device...part of China. The Fifth Electronic Research Institute's aim is to accelerate the ...
- Diabetes Research Institute Foundation Teams Up With VitaZest(R) Vitamin &...
- Press release article from: PR Newswire September 12, 2006 700+ words
...12 /PRNewswire/ -- The Diabetes Research Institute Foundation and VitaZest(R) Vitamin...VitaZest sales will support the Diabetes Research Institute Foundation, a nonprofit organization...at the world-renowned Diabetes Research Institute (DRI) at the University of Miami...