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2003 MAY 8 - (NewsRx.com & NewsRx.net) -- When the Journal of the American Medical Association reported that women who took estrogen for 10 years or more after menopause were twice as likely to die of ovarian cancer as nonusers, many of the 20 million Americans who used estrogen alone or in combination therapy, stopped taking the hormone.
But if they were postmenopausal and hypertensive, they were abandoning a therapy that appeared to be useful in lowering blood pressure.
Now, a new research study finds that a diet moderately high in grape seed extract can blunt sodium chloride-sensitive hypertension to about the same extent as treatment with either plant estrogens or 17beta-estradiol. This suggests that mechanisms other than the estrogen receptor activation actually provide the beneficial effects of estrogen therapy and that grape seed extract may be a useful supplement to blunt hypertension and other cardiovascular symptoms in postmenopausal women.
These findings may be significant for the increasing number of women entering middle age. Hypertension becomes more prevalent with increasing age, and at all ages and in both sexes it afflicts African Americans more often than whites. Men with hypertension outnumber women with hypertension during young adulthood and early middle age, but hypertension rapidly increases in women after the age of menopause, and they soon outnumber men with hypertension.
Hypertension is strongly, continuously, and independently related to coronary artery disease (CAD), stroke, renal disease, and all-cause mortality. Past research has found that for every 7.5 mm Hg increase in diastolic blood pressure, the risk for coronary heart disease increases 29% and stroke risk increases 46%. These risks have been shown for women as well as for men.
Physiologists from Alabama previously found that plant estrogens from soy reduce salt-sensitive hypertension in young, estrogen-depleted spontaneously hypertensive rats (SHR).
In the current study this group examined whether the polyphenols in grape seed extract (primarily ...
Source: HighBeam Research, Grape seed extract may be a useful supplement in postmenopausal women.