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Antibodies against PsaA inhibit pneumococcal adherence to nasopharyngeal cells.
2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Antibodies against surface adhesin A (PsaA) inhibited pneumococcal adherence to human nasopharyngeal epithelial cells.
According to published research from the United States, "The role of pneumococcal (Pnc) surface adhesin A (PsaA) in the adherence of Streptococcus pneumoniae (pneumococcus) to host cells is not well defined. We examined the effect of anti-PsaA antibodies in an inhibition of adherence assay using Detroit 562 nasopharyngeal human epithelial cells."
"Rabbit polyclonal (Pab) anti-recombinant PsaA (rPsaA) sera, a purified mouse monoclonal antibody (MAb) (MAb 6F62G8E12), and 22 healthy adult sera with known anti-PsaA IgG levels (obtained by enzyme-linked immunosorbent assay) were evaluated for their abilities to inhibit Pnc adherence to confluent monolayers (measured as percent reduction in CFU counts compared to those of uninhibited controls)," stated Sandra Romero-Steiner and colleagues at the Centers for Disease Control and Prevention.
The authors wrote, "Pnc adherence was dependent on capsular phenotype (no or low adherence for opaque strains). With an inoculum of 10[superscript]4 to 10[superscript]5 bacteria/well, the mean[+ or -]standard deviation count in controls was 163[+ or -]32 CFU/well for transparent strains. Low adherence was observed for a PsaA-minus mutant even at higher inoculum doses.
"Mean percent inhibitions of adherence with Pab and MAb were 54 and 50%, respectively. Adult sera showed inhibition in a dose-response fashion with a range of 98 to 8%, depending on the serum anti-PsaA antibody concentration. Absorption of ...
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Source: HighBeam Research, Antibodies against PsaA inhibit pneumococcal adherence to...