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CpG enhances antibody response against hepatitis C virus core protein.
2003 MAY 7 - (NewsRx.com & NewsRx.net) -- CpG immuno-stimulatory motifs enhanced the humoral, but not the cellular, immune responses against hepatitis C virus core protein after DNA-based immunization.
According to published research from the United States, "Chronic HCV infection is associated with a high morbidity and mortality rate, and currently a prophylactic or therapeutic vaccine is not available. DNA-based immunization is a powerful method to generate cellular and humoral immune responses. However, DNA immunization against HCV core results only in a weak humoral immune response demonstrated in several studies."
"Therefore, co-immunization with a novel adjuvant may enhance such potentially important immune responses," said Jens Encke and colleagues at Harvard Medical School. "We examined whether unmethylated CpG motifs in the form of oligodeoxynucleotides (ODN) or E. coli DNA can act as adjuvants for a DNA vaccination approach, since CpG motifs have been shown to stimulate the innate immune system as well as B and T cell immune reactivity. The present study demonstrates that CpG motifs enhance in vivo antibody levels after DNA immunization against HCV core. However, despite some in vitro activity of CpG ...
- Direct evidence of TLR9 interaction with CpG motifs reported.
- Newspaper article from: Drug Week May 28, 2004 700+ words
...DNA has been reported. "Cytosine-phosphate-guanine (CpG) motifs in bacterial DNA are known to activate the mammalian immune...suggested that TLR9 is involved as the specific receptor for CpG motifs but did not provide direct evidence of their interaction...
- Dynavax Announces the Identification of Novel Short CpG Motifs That Can Be...
- Press release article from: PR Newswire September 2, 2003 700+ words
BERKELEY, Calif., Sept. 2 /PRNewswire/ -- Dynavax Technologies today announced the development and characterization of a novel series of CpG-containing molecules with potent immune regulation activities in human cells. These molecules, termed Chimeric Immunomodulatory Compounds (CICs), consist of
- Dynavax announces the identification of novel short CpG motifs that can be...
- News wire article from: Asia Africa Intelligence Wire September 2, 2003 700+ words
(From Chemical Business NewsBase - Press Release) Dynavax Technologies (Dynavax) announced the development and characterization of a novel series of CpG-containing molecules with potent immune regulation activities in human cells. These molecules, termed Chimeric Immunomodulatory Compounds (CICs),
- The Immune Response Corporation Announces Study Suggesting Protection From HIV...
- Press release article from: PR Newswire October 17, 2002 700+ words
...Vaginal HIV-Specific Immune Responses Resulting From Innovative...containing immunostimulatory CpG motifs (CpG ODN) induces HIV-specific immune responses in genital and vaginal...protection and potent immune responses in the genital tract...
- The Immune Response Corp announces study suggesting protection from HIV...
- News wire article from: Asia Africa Intelligence Wire October 17, 2002 700+ words
...containing immunostimulatory CpG motifs (CpG ODN) induces HIV-specific immune responses in genital and vaginal...protection and potent immune responses in the genital tract...vaginal and systemic immune responses and protection from...
- CpG is not effective adjuvant to Toxoplasma gondii vaccination.
- Newspaper article from: Biotech Week June 2, 2004 700+ words
...dinucleotides have been found to stimulate general immune responses in mammals. CpG motifs have further been shown to be potent adjuvants...determine whether these CpG motifs will also enhance immune responses in parasitic diseases," researchers in the...
- Study: Remune antigen with CpG ODN may offer HIV protection.(Brief Article)
- Newspaper article from: AIDS Weekly December 16, 2002 700+ words
...containing immunostimulatory CpG motifs (CpG ODN) induces HIV-specific immune responses in genital and vaginal...protection and potent immune responses in the genital tract...vaginal and systemic immune responses and protection from...
- Study: Remune antigen with CpG ODN may offer HIV protection.
- Newspaper article from: Vaccine Weekly December 18, 2002 700+ words
...containing immunostimulatory CpG motifs (CpG ODN) induces HIV-specific immune responses in genital and vaginal...protection and potent immune responses in the genital tract...vaginal and systemic immune responses and protection from...
- Hybridon Identifies Novel Synthetic Immunostimulatory Motif in Oligonucleotides...
- Press release article from: PR Newswire December 2, 2003 700+ words
...oligonucleotides containing CpG motifs (CpG DNA) activate innate and adaptive immune responses in vertebrates by...DNA to induce these immune responses has been shown to...by TLR9 and induced immune responses in cells from pig...
- Dynavax Awarded $8.4 Million in NIH Biodefense Grants to Develop Novel...
- Press release article from: PR Newswire September 29, 2003 700+ words
...capable of generating robust and specific immune responses," said Dino Dina, M.D., president...synthetic DNA sequences containing CpG motifs that act as signaling molecules to enhance immune responses against foreign pathogens and cancer...
Source: HighBeam Research, CpG enhances antibody response against hepatitis C virus core protein.