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Cytokine polymorphisms modulate UVB-induced immune responses to HBV vaccine.
2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Cytokine polymorphisms play a role in susceptibility to ultraviolet B-induced modulation of immune responses after hepatitis B vaccination.
"UVB exposure can alter immune responses in experimental animals and humans. In an earlier human volunteer study, we demonstrated that hepatitis B-specific humoral and cellular immunity after vaccination on average were not significantly affected by UVB exposure. However, it is known that individuals differ in their susceptibility to UVB-induced immunomodulation, and it was hypothesized that polymorphisms in specific cytokines may play a role in this susceptibility," researchers in the Netherlands and United States report.
"In this respect, we previously demonstrated that immune responses after hepatitis B vaccination are influenced by the minor allelic variant of IL-1-beta in the general population," said Annemarie Sleijffers and colleagues at the National Institute of Public Health and the Environment in Bilthoven, the Leiden University Medical Center in Leiden, University Medical Center in Utrecht, and the National Institute for Occupational Safety and Health in the United States.
The authors continued, "For all volunteers, single nucleotide polymorphisms were determined for the following UV response-related cytokines: IL-1 receptor antagonist (+2018), IL-1-alpha (+4845), IL-1-beta (+3953), TNF-alpha (-308), and TNF-alpha (-238). Exposure to UVB ...
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Source: HighBeam Research, Cytokine polymorphisms modulate UVB-induced immune responses to HBV...