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Mast cell-derived exosomes induce maturation of dendritic cells.
2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Mast cell-derived exosomes induced phenotypic and functional maturation of dendritic cells and elicited specific immune responses in vivo.
"Mast cells (MCs) are considered major players in IgE-mediated allergic responses, but have also recently been recognized as active participants in innate as well as specific immune responses. Recent work provided evidence that MCs are able to activate B and T lymphocytes through the release of vesicles called exosomes. Here we demonstrate that exosomes, which are located in the endocytic pathway, harbor exogenous antigens that associate with other molecules endowed with immunomodulatory functions, including 60- and 70-kDa heat shock proteins," investigators in France and Germany report.
"Administration to naive mice of antigen-containing exosomes in the absence of conventional adjuvants elicits specific antibody responses across the MHC II haplotype barrier," stated Dimitris Skokos and collaborators at the Institut Pasteur in France and the University of Leipzig in Germany. "We demonstrate that MC-exosomes induce immature dendritic cells (DCs) to up-regulate MHC class II, CD80, CD86, and CD40 molecules and to acquire potent antigen-presenting ...
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Source: HighBeam Research, Mast cell-derived exosomes induce maturation of dendritic cells.