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CD4+ cells play critical role in tumor immunity against simian virus 40 antigen.
2003 MAY 7 - (NewsRx.com & NewsRx.net) -- CD4+ T lymphocytes played a critical role in antibody production and tumor immunity against simian virus 40 large tumor antigen.
According to recent research published in the journal Cancer Research, "The role of CD4+ T lymphocytes in antitumor immunity has been largely attributed to providing signals required for the priming of MHC class I-restricted CD8+ cytotoxic T lymphocytes, and CD8+ cytotoxic T lymphocytes are thought to serve as the predominant mediators of tumor killing in vivo. We decided to evaluate the role of T lymphocyte subsets in tumor immunity induced by recombinant SV40 large tumor antigen (Tag) within an experimental murine pulmonary metastasis model of SV40 Tag-expressing tumors."
"Studies in BALB/c mice used in vivo depletion of either CD4+ or CD8+ T cells in the induction phase of the immune response to SV40 Tag," reported Ronald C. Kennedy and collaborators at Texas Tech University. "These studies indicate that CD4+ T cells but not CD8+ T cells were critical in the production of antibodies to SV40 Tag and in tumor immunity as the result of recombinant SV40 Tag immunization. On the basis of the predominance of the IgG1 isotype in the antibody response to ...
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- Newspaper article from: Cancer Weekly July 13, 2004 700+ words
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- Animal models of tumor immunity and cancer vaccines reviewed.
- Newspaper article from: Biotech Week May 26, 2004 700+ words
...NewsRx.net) -- A researcher reviews animal models of tumor immunity, immunotherapy, and cancer vaccines in a recent issue...study in Current Opinion in Immunology (Animal models of tumor immunity, immunotherapy, and cancer vaccines. Curr Opin Immunol...
Source: HighBeam Research, CD4+ cells play critical role in tumor immunity against simian virus...