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DNA vaccine protects mice against a lethal vaccinia virus challenge.
2003 MAY 7 - (NewsRx.com & NewsRx.net) -- A four-gene-combination DNA vaccine protected mice against a lethal vaccinia virus challenge and elicited appropriate antibody responses in nonhuman primates.
According to published research from the United States, "Two major infectious forms of vaccinia virus (VACV) have been described: the intracellular mature virion (IMV), and the extracellular enveloped virion (EEV). Due to their stability in the environment, IMVs play a predominant role in host-to-host transmission, whereas EEVs play an important role in dissemination within the host."
"In a previous report, we demonstrated that mice vaccinated with VACV L1R (IMV immunogen) and A33R (EEV immunogen) were protected from a lethal poxvirus challenge," reported Jay W. Hooper and colleagues at the United States Army Medical Research Institute for Infectious Diseases in Fort Detrick, Maryland. "Vaccination with a combination of both genes conferred greater protection than either gene alone, suggesting that an immune response against both IMV and EEV is advantageous. Here, we report that in mice individually administered DNA vaccines with two different VACV immunogens, A27L (IMV immunogen) or B5R (EEV immunogen), failed to significantly protect; however, vaccination with a combination of both genes conferred a high level of protection. Mice were completely protected when vaccinated with a combination of four ...
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...spread of the live attenuated vaccinia virus is considered the predominant...have measured the presence of vaccinia virus on the dressings or hands...however, the recovery of vaccinia virus in the environment has not...
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- Newspaper article from: Drug Week January 30, 2004 700+ words
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...the humoral immune response against vaccinia virus. According to published research from...to evaluate the immune response to vaccinia virus need to be developed. Neutralization...presence of neutralizing antibodies to vaccinia virus is measured using a plaque reduction...
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- Newspaper article from: Vaccine Weekly October 14, 2009 700+ words
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"The vaccinia virus double-stranded RNA binding protein...Winnipeg, Canada report (see also Vaccinia Virus). "Using real-time PCR arrays...of cells with RNA isolated from vaccinia virus-infected cells. Moreover, we...
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- Newspaper article from: Morbidity and Mortality Weekly Report Barkdoll, TW Cabiad, RB Tankersley, MS Adkins, JL Jilly, B Herriford, G Whelen, AC Bell, CA Fairchok, MP Raynor, LC Garde, VA Rothmeyer, VM Mahlen, SD Engler, RJ Collins, LC Duran, LL Huynh, MT Bradshaw, RD Grabenstein JD February 13, 2004 700+ words
...vaccination program (1). Because vaccinia virus is present on the skin at the site...describes cases of contact transfer of vaccinia virus among vaccinated military personnel...findings indicate that contact transfer of vaccinia virus is rare. Continued efforts are needed...
Source: HighBeam Research, DNA vaccine protects mice against a lethal vaccinia virus challenge.