Dendritic cell-derived CC chemokine 1 enhances protective immunity to malaria.

2003 MAY 7 - (NewsRx.com & NewsRx.net) -- The dendritic cell-specific chemokine, dendritic cell-derived CC chemokine 1, enhanced protective cell-mediated immunity to murine malaria.

According to a study from the United States, Spain, and Austria, "Cell-mediated immunity plays a crucial role in the control of many infectious diseases, necessitating the need for adjuvants that can augment cellular immune responses elicited by vaccines. It is well established that protection against one such disease, malaria, requires strong CD8+ T cell responses targeted against the liver stages of the causative agent, Plasmodium species."

"In this report we show that the dendritic cell-specific chemokine, dendritic cell-derived CC chemokine 1 (DC-CK1), which is produced in humans and acts on naive lymphocytes, can enhance antigen-specific CD8+ T cell responses when co-administered with either irradiated Plasmodium yoelii sporozoites or a recombinant adenovirus expressing the P. yoelii circumsporozoite protein in mice," reported Oscar Bruna-Romero and colleagues at New York University in the U. S., the Instituto de Salud Carlos III in Spain, and Intercell AG in Austria. "We further show that these enhanced T cell responses result in increased protection to malaria in immunized mice challenged with live P. yoelii sporozoites, revealing an adjuvant activity for ...