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Peptide on virus-like particles protects mice against Japanese encephalitis.
2003 MAY 7 - (NewsRx.com & NewsRx.net) -- A Japanese encephalitis virus peptide present on Johnson grass mosaic virus-like particles induced virus-neutralizing antibodies that protected mice against a lethal challenge.
According to recent research published in the Journal of Virology, "Protection against Japanese encephalitis virus (JEV) is antibody dependent, and neutralizing antibodies alone are sufficient to impart protection. Thus, we are aiming to develop a peptide-based vaccine against JEV by identifying JEV peptide sequences that could induce virus-neutralizing antibodies."
"Previously, we have synthesized large amounts of Johnson grass mosaic virus (JGMV) coat protein (CP) in Escherichia coli and have shown that it auto-assembled to form virus-like particles (VLPs)," reported Manisha Saini and Sudhanshu Vrati at the National Institute of Immunology in New Delhi. "The envelope (E) protein of JEV contains the virus-neutralization epitopes. Four peptides from different locations within JEV E protein were chosen, and these were fused to JGMV CP by recombinant DNA methods. The fusion protein auto-assembled to form VLPs that could be purified by sucrose gradient centrifugation."
The investigators found, ...
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Source: HighBeam Research, Peptide on virus-like particles protects mice against Japanese...