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RANTES and CpG oligodeoxynucleotides effective adjuvants in SIV vaccine.
2003 MAY 7 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - RANTES and CpG oligodeoxynucleotides (ODN) functioned as adequate substitutes for the cholera toxin (CT) as potent adjuvants for a simian immunodeficiency virus (SIV) virus-like particle (VLP) vaccine, according to a report in the Journal of Virology.
"Cholera toxin is the most potent known mucosal adjuvant, but its toxicity precludes its use in humans," commented Sang-Moo Kang and Richard W. Compans at Emory University in the United States.
Kang and Compans compared the adjuvant activities of RANTES, CpG ODN, and CT by co-delivery of each adjuvant with SIV VLPs intranasally.
"Antibody analysis demonstrated that RANTES and CpG ODN had capacities for mucosal adjuvanticity, i.e., for enhancing serum and vaginal antibodies specific to SIV Env, similar to those for CT," reported the researchers. "RANTES and CpG ODN skewed serum antibodies predominantly to the immunoglobulin G2a isotype."
RANTES and CpG ODN were more effective than CT at stimulating the production of neutralizing titers of serum and vaginal antibodies. The two alternative adjuvants also elicited greater production of lymphocytes that produced gamma interferon and higher levels of cytotoxic T cells in lymph nodes and the spleen after intranasal co-delivery with SIV VLPs than did CT. However, RANTES and CpG ODN did not cause an increase in lymphocytes that secreted interleukin-4.
"The ...
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Source: HighBeam Research, RANTES and CpG oligodeoxynucleotides effective adjuvants in SIV...