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Drugs used for multiresistant infections safe during pregnancy.(Brief Article)
2003 MAY 1 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Agents used to treat multidrug-resistant tuberculosis (MDR-TB) are safe for pregnant women and their unborn children, researchers in the United States and Peru report.
MDR-TB "is a global public health problem affecting women of childbearing age," according to Sonya Shin and colleagues at Harvard Medical School and Brigham and Women's Hospital in Boston, and the Ministry of Health in Lima.
Drugs effective against MDR-TB maintain their efficacy during pregnancy, and do not appear to cause obstetric complications, Shin and coauthors found.
The researchers used anti-MDR-TB agents to treat seven pregnant women with severe, chronic tuberculosis. All seven infections were highly resistant to conventional anti-TB therapy, according to the report.
Treatment failure was seen in only one of the seven women, although another patient "abandoned" therapy before efficacy could be determined, study data showed. The other five women remained culture-negative at last follow-up.
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