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MPA improves inspiratory flow shapes during sleep in postmenopausal women.(medroxyprogesterone acetate)
2003 MAY 1 - (NewsRx.com & NewsRx.net) -- Medroxyprogesterone acetate-induced respiratory stimulation improves inspiratory flow shapes during sleep in postmenopausal women, study results show.
Earlier work by T. Saaresranta and colleagues at the Turku Center for Computational Science in Finland demonstrated "that medroxyprogesterone acetate (MPA) effectively decreases the arterial CO[subscript]2 levels in postmenopausal women with partial upper airway obstruction."
In their current study, the group assessed MPA's effects on the inspiratory flow shapes in eight postmenopausal women with hypoxemia and partial upper airway obstruction during sleep. The women were administered 60 mg MPA daily for 14 days. Controls were four matched, postmenopausal women who didn't receive MPA.
"Sleep and nasal pressure were recorded on each visit. Each breath was analyzed for duration, volume, and inspiratory flow shape class," the researchers said.
Among their findings:
* MPA shortened inspiration and prolonged expiration.
* Inspiratory volumes increased consistently in all flow shape classes.
- MPA improves inspiratory flow shapes during sleep in postmenopausal...
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