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Overexpression and secretion of angiogenin may play a role in IUGR.(intrauterine growth retardation )
2003 MAY 1 - (NewsRx.com & NewsRx.net) -- Researchers in Singapore suggest that the significantly higher levels of angiogenin they observed in intrauterine growth retardation placenta "may provide a molecular mechanism for the abnormal placental development."
"Human angiogenin is a potent inducer of neovascularization. There is a strong evidence to suggest that it might be involved in morphological and angiogenic changes in the placenta, that are necessary for a successful fetal outcome during pregnancy. However, its precise role in the pathogenesis of abnormal pregnancies is yet unknown," wrote G. Rajashekhar and colleagues.
"Intrauterine growth retardation (IUGR) ... is not a specific disease entity per se, but rather a manifestation of many possible fetal and maternal disorders. In this study, we demonstrated, for the first time, that placental explants in vitro secrete significantly elevated levels of angiogenin in placental tissues from patients with IUGR. "We also observed enhanced mRNA expression in placenta from these patients," the researchers reported.
In IUGR and normal placenta, angiogenin stained identically to villous syncytiotrophobalst and fetal endothelial cells, they found.
"Functionally active placental explants were used to detect immunoreactive angiogenin in conditioned media of all the samples from IUGR placenta and normal term group," according to the researchers' report.
They recorded ...
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Source: HighBeam Research, Overexpression and secretion of angiogenin may play a role in...