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Weight gain stimulates hyperleptinemia in patients with anorexia nervosa.
2003 MAY 1 - (NewsRx.com & NewsRx.net) -- Weight gain stimulated hyperleptinemia in patients with anorexia nervosa.
"Previously it was shown that hyperleptinemia ensues from the therapeutically induced weight gain in patients with anorexia nervosa (AN). However, not all studies have been able to confirm this finding," scientists writing in the Journal of Psychiatric Research report.
"To further investigate leptin secretion during weight gain in AN and potential functional implications serum leptin levels, body mass index (BMI), % body fat, fT3, fT4, and TSH of 18 adolescent AN patients (BMI at admission: 14.4[+ or -]1.2) were examined four times during 11 weeks of re-feeding and compared to 18 weight stable controls," stated Kristian Holtkamp and colleagues at Technical University Aachen in Germany. "Additionally, serum leptin levels, BMI and % body fat were determined in patients reaching target weight after 11-20 weeks (mean 14.3[+ or -]3) of inpatient re-feeding."
The investigators found, "At admission patients showed lower lg[subscript]10 leptin levels (p=0.000) and BMI (p=0.000) than controls. At target weight patients still had significantly lower BMI (p=0.000) and % body fat (p=0.000) than controls but lg[subscript]10 leptin levels of patients were higher than those of controls when adjusted for BMI and % body fat (ANCOVA, group p=0.038).
"In patients, correlation coefficients between lg[subscript]10 leptin levels and BMI increments increased during the 11 weeks of re-feeding. BMI, % body fat ...
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Source: HighBeam Research, Weight gain stimulates hyperleptinemia in patients with anorexia...