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The health of the industry.(From the Editor)(Letter to the Editor)
March 1, 2005... A casual observer of the pharmaceutical industry might think that recent drug safety issues and testimony before Congress on drug safety reform has paralyzed the industry; that the industry is sitting and waiting for resolution of these and...
Ultra-sanitary screener meets cGMP and FDA standards.(What's Hot)
March 1, 2005... The Vibroscreen[R] features gap-free screen frames, quick-release "U" clamps, radius corners, a domed lid, an Air-Lift device to raise the frames, continuous ground and polished welds, a gap-free and crevice-free interior finished to sanitary...
Foil offers high barrier performance for pharmaceutical applications.(What's Hot)
March 1, 2005... Flexi 6611 features (outside to inside) polyester/adhesive/aluminum foil/adhesive/ clear polyethylene to achieve moisture vapor and oxygen permeability which are key performance characteristics for many products.
Flexicon, Cary, IL 60013....
Control valve designed for boiler feed-pump recirculation solution.(What's Hot)
March 1, 2005... The Multi-Z is designed specifically to handle high-pressure drop applications where entrained solids are a problem, and is ideal for system start-up and boiler-feed water recirculation. The valve features a multistage trim design that...
Barrier isolator meets the requirements of USP 797.(What's Hot)
March 1, 2005... The Laminar Flow Glovebox/Isolator (LFGI) can be configured, either at the factory or in-place, to exhaust 100%, a portion or none of the air from the work area. The LFGI can thus meet the recommendation from NIOSH for no recirculation (100%...
Automatic balance improved for weighing capsules and tablets.(What's Hot)
March 1, 2005... The AB PLUS automatic balance system is designed to weigh capsules, tablets and small parts automatically without the need for an operator. Unit is ideal for clinical batch and initial press start-up sorting. The AB PLUS can be used with any...
Thermoplastic air release valves expel unwanted air from pipelines.(What's Hot)
March 1, 2005... Series ARV thermoplastic air release valves expel unwanted air from a pipeline at system start-up. They are also ideal for venting air from a tank or vessel during filling. Valves feature a unique self-guided poppet that offers reliable...
Multifunction centrifuges feature quick-change rotors.(What's Hot)
March 1, 2005... The B4i and C3i multifunction centrifuges are available in ventilated and refrigerated versions. Ideal for clinical biology, these centrifuges have a high capacity swing-out rotor (4 x 290 mL);, are equipped with a quiet, brushless induction...
Upgraded biochromatography systems feature improved accuracy and reproducibility.(What's Hot)
March 1, 2005... Line of Bioprocess LC systems can now be upgraded to the company's patent pending Adaptive PAT technology. The upgraded system is in full compliance with 21 CFR Part 11 and includes full IQ/QQ validation as well as GAMP-4 software validation....
Prepackaged reagents designed for HPLC mobile phase preparation.(What's Hot)
March 1, 2005... Company uses GMP procedures to prepare standard off-the-shelf or custom blended chemistry solutions. Solutions are packaged in patented CHEM+NECT flexible film packaging system. CHEM+NECT packaging ensures sterile, filtered and de-gassed...
Turnkey design/build cleanroom services for critical applications.(What's Hot)
March 1, 2005... Company offers turnkey design and installation of Class 1 through Class 100,000 cleanrooms, designed to the latest cGMP and ISO 14644 standards and 21CFR11 compliance. Company integrates the validation process with the construction of its...
Solid PTFE rupture disk holder resists failure.(What's hot: processing components)
March 1, 2005... Fluoropolymer-booted insert holder is constructed with a solid PTFE resin insert pressed into the inner diameter of a stainless steel holder. When used with a Fluoropolymer lined rupture disk, only Fluoropolymer is in contact with the corrosive...
Photoelectric sensor features four sensing modes.(What's hot: processing components)
March 1, 2005... The PhotoVirtu features diffuse, background suppression, polarized retroreflective and thru-beam modes and provides optional light or dark operate functionality. The unit is teachable with an external, removable pushbutton providing convenience...
The packaging is part of the prescription--partnering with packagers.(Cover Story)
March 1, 2005... Dramatic transformations in healthcare are strongly reverberating in the pharmaceutical packaging industry. New challenges put packaging in the spotlight as never before, making the idea of packaging as an afterthought in the development of...
Outsourcing unit adds bar-coded unit dose packaging to its list of capabilities.(Outsourcing: cool technology)
March 1, 2005... Mallinckrodt Pharmaceuticals Outsourcing, a business unit of Mallinckrodt Inc., recently announced the addition of a unit dose packaging line that produces blister cards that are bar-coded to the unit of use. Bar coding assists healthcare...
Company offers R&D and technical services to the industry.(Outsourcing: cool technology)
March 1, 2005... Company's services include research, development, technical services, technical training and value added ingredients. Company provides delivery system development, extensive expertise and technical service in: oral solid dosage forms;...
Process synthesis services for the pharmaceutical industry.(Outsourcing: cool technology)
March 1, 2005... Company provides integrated solutions in the field of process synthesis and development to the chemical and pharmaceutical industries. Process development is a multidisciplinary exercise for creating the best process for manufacturing the...
Filter validation service program evaluates processes and protocols.(Outsourcing: cool technology)
March 1, 2005... CONFIDENCE[R] is the company's Filter Validation Services program. Using your product formulation under simulated 'worst-case' process conditions, the company will evaluate your process and provide test protocols for Bacterial Challenge...
Permeability Testers provide reliable measurements.(Outsourcing: packaging)
March 1, 2005... The OPT-5000 Oxygen Permeability Tester with automated temperature control and single- or dual-side relative humidity control accommodates a broad range of lab and production applications. An operator simply inserts a sample and selects the...
Inspection machine features integrated parts handling.(Outsourcing: packaging)
March 1, 2005... Systems include Cognex, DVT, Omron or Keyence vision equipment along with PLC, part gripper and controls to interface with the user's machine. Systems can incorporate conveyors, feeder bowls, robotics, pneumatics, or custom operator interface...
Plastic components are contamination-free.(Outsourcing: processing components)
March 1, 2005... Precision machined plastic components are available in FDA compliant Acetal, UHMW, PVC, Teflon and other materials that can be machined into parts such as slides, housings, pulleys, leadscrews and threaded fittings.
Drummond Corporation,...
Submersible level sensor designed for low level measurement.(Outsourcing: processing components)
March 1, 2005... The CTU9000CS offers measurement for low level ranges from 3.3 feet of water full scale. Due to its outside diameter of only 21.8 mm, these transmitters are ideal for use in small-diameter probe tubes or tanks with small apertures. An all...
Batch or continuous processing: a choice.(Applications)
March 1, 2005... Most pharmaceuticals are organic or inorganic chemicals synthesized and then converted into an easily administrable dosage form for human consumption. This conversion can involve combining the active ingredient with inert materials to...
Module designed for use with multi-function tester.(Outsourcing: processing components)
March 1, 2005... The VMA0055 is a voltage and current measurement and simulation module for use with the company's handheld Multi-Function Tester (MFT) 4000 Series features mA sourcing, transmitter output simulation, and loop power sourcing. Measurement ranges...
Linear slides and table assemblies are maintenance free and FDA compliant.(Outsourcing: processing components)
March 1, 2005... Slide Rail linear slides and table assemblies are ideal for applications requiring smooth motion, low noise, and/or washdown capabilities. Units are maintenance-free and easy to integrate into new and existing applications.
LM76, E....
Keeping a lock on change.(Pharma-IT)
March 1, 2005... Sometimes, change isn't good. And, when your manufacturing processes must meet tight FDA regulations, any change needs to be authorized and documented.
Fortunately, Change Management Systems (CMS) have been around for more than 20 years...
Welcome to INTERPHEX.
March 1, 2005... A scientist's aim in a discussion with his colleagues is not to persuade, but to clarify.--Leo Szilard
Dear Colleague,
On behalf of Pharmaceutical Processing, ISPE, our many sponsors and endorsers and the entire show management team,...
Feeders provide precise size reduction.(Exhibitor Preview)
March 1, 2005... AccuRate[R] volumetric and gravimetric feeders routinely meter dry pharmaceutical powders into jet mills used to do fine grinding. By accurately and consistently charging the jet mill, the milling process, and particle size uniformity are...
Silicone components designed for aseptic applications.(Exhibitor Preview)
March 1, 2005... Molded silicone components for pharmaceutical, biopharmaceutical, sanitary process, and laboratory applications consist of stoppers and sealing systems for carboys and vessels, bottles, laboratory equipment, and process and storage containers....
Cantilever roller compactor series includes small lab units to production machines.(Exhibitor Preview)
March 1, 2005... Expanded line of roller compactors includes a range of units that include small laboratory systems up to high-throughput production machines. Smaller sized units can process as little as 10 grams and can be accurately scaled up to the larger...
Controller designed for pressure, velocity and flow applications.(Exhibitor Preview)
March 1, 2005... The Series DH DigiHelic[R] Differential Pressure Controller is ideal for pressure, velocity and flow applications, achieving a 0.5% full scale accuracy on ranges from 5" w.c. to 100" w.c. The DigiHelic[R] provides a 4-20 mA process output, 2...
Sampling and transfer assemblies ideal for sterile and aseptic applications.(Exhibitor Preview)
March 1, 2005... Ame-Collect silicone tube assemblies are used for sterile transfers and aseptic sampling in fermentation, cell culture, and laboratory applications. The pre-packaged sets offer the user cost savings, reduce potential for sterility issues, and...
Batch mixers offer pharmaceutical grade motor.(Exhibitor Preview)
March 1, 2005... The Rotomixx offers a pharmaceutical grade stainless motor, where an internal proximity sensor can be installed to read actual motor shaft speed with Digital Readout (DRO) either on the unit or remotely mounted. The Rotomaxx is designed for...
Nowoven wipers combine cleanliness with sorbency.(Exhibitor Preview)
March 1, 2005... The Captura family of nonwoven wipers delivers sorbent wipers for the pharmaceutical industry. These products are constructed from proprietary rayon producing a fabric that combines cleanliness with sorbency. Sterilization as well as...
Valves and control products provide high performance solutions.(Exhibitor Preview)
March 1, 2005... The Dymatfix line of specialty valves and control products are designed to provide high performance solutions for Chemical Mechanical Planarization (CMP) processes and ultrapure water and chemical applications.
Asahi/America, Inc., Malden,...
Single-use mixing system increases manufacturing uptime.(Exhibitor Preview)
March 1, 2005... The Newmix single-use bioprocess has been designed for the biopharmaceutical industry to reduce total processing cost, increase manufacturing uptime and reduce risk of cross-contamination while protecting the environment. New mix integrates the...
Vision sensor delivers high-speed error-proofing and inspections.(Exhibitor Preview)
March 1, 2005... The PresencePLUS[R] P4 EDGE vision sensors are designed for high-speed inspection and error-proofing applications. Able to accurately sense and evaluate over 10,000 objects-per-minute, the P4 EDGE is ideal for validating the height and width of...
Low volume industrial dispenser offer maintenance-free fluid control.(Exhibitor Preview)
March 1, 2005... The IDS-2000ARH Industrial Dispense Pump is CE approved and integrates patented CeramPump[R] valveless piston pumping principals with precision stepper control. The valveless design has only one moving part, a single rotating and reciprocating...
Pre-Lyophilized Inspection Machine improves product quality.(Exhibitor Preview)
March 1, 2005... The PLIM performs particle inspection prior to the lyophilization process. It's a camera-based system that gently handles the vial and detects particulate matter in the liquid that, after freeze drying, cannot be detected accurately.
Eisai...
Explosion suppression system operates without explosive actuators.(Exhibitor Preview)
March 1, 2005... The PistonFire discharges an explosion suppressant into a process vessel in milliseconds without the use of explosive actuators. It is safe to transport and store and features a supervisory switch that meets OSHA requirements.
Fenwal...
Dust collectors feature versatile environmental control booth.(Exhibitor Preview)
March 1, 2005... Family of Downflo[R] Oval dust collectors features the new Downflo[R] WorkStations. These workstations offer maximum productivity through better performance, longer filter life and greater filtration capacity. Donaldson Co., Inc., Minneapolis,...
Ready-to-fill syringes available in glass and plastic.(Exhibitor Preview)
March 1, 2005... The company's range of prefillable syringes will be on display. Product range also features dropper and spray bottles, inhalers, applicators, vein catheters and medical devices as well as special closures. Gerresheimer Group GmbH, Dusseldorf,...
Paperless recorder is 21 CFR Part 11 compliant.(Exhibitor Preview)
March 1, 2005... The LOGOSCREEN es and the associated PC software components enables secure data acquisition, archiving and evaluation of GMP-relevant process data in the pharmaceutical industry.
JUMO Process Control, Inc., Coatesville, PA 19320. Call...
TOC Analyzers offer improved performance.(Exhibitor Preview)
March 1, 2005... The three-model 900 Series includes the 900 Laboratory, 900 On-Line, and 900 Portable TOC Analyzers, offering improved analytical performance, ease of use, productivity, and reliability.
Ionics Instruments, Boulder, CO 80301. Call...
Mixing system reduces maintenance and improves quality.(Exhibitor Preview)
March 1, 2005... The Master Plant features a high-shear mixer that pumps, disperses, and incorporates powders or liquids, all in one machine. An additional inlet to the suction area allows for connection of a funnel or other feeding device.
IKA Works,...
Ultrafiltration cartridges ideal for lab applications.(Exhibitor Preview)
March 1, 2005... The SelRO nanofiltration membranes provide chemical and thermal stability to satisfy the demanding requirements of pharmaceutical processes involving high and low pH, high temperature and organic solvents media.
Koch Membrane Systems,...
Coriolis mass flowmeter eliminates installation requirements.(Exhibitor Preview)
March 1, 2005... The OPTIMASS Series 7000 offers easy installation and superior performance in density and mass flow. The meter meets the stringent hygienic requirements for food and pharmaceutical applications.
Krohne Inc., Peabody, MA 01960. Call...
Fermentors and bioreactors feature modular design.(Exhibitor Preview)
March 1, 2005... BioFlo[R] Pro fermentors and bioreactors are modular in design, offering ready customization, quick delivery, and the ability to expand system capabilities as needs change.
New Brunswick Scientific, Edison, NJ 08818. Call 800-631-5417.
...
Prefilter combines benefits of membrane and depth filters.(Exhibitor Preview)
March 1, 2005... The Protec RM0.5 is designed with an outer layer of glass fiber and an inner layer of hydrophilic PVDF membrane. Design combines the flow rates and high dirt-holding capacity of a glass medium with the particle retention of a membrane filter....
Micro-feeder offers draft shield.(Exhibitor Preview)
March 1, 2005... The Micro Feeder Model MT12 is a loss-in-weight feeder that can utilize an optional draft shield. The MT12 accurately feeds rates as low as 20 grams/hour and as high as 2000 grams/hour.
K-Tron Feeder Group, Pitman, NI 08071. Call...
Filler/closer designed for products from liquids to pastes.(Exhibitor Preview)
March 1, 2005... The Flexofill is a monoblock machine that is a combination filler and closer ideal for products from liquid to paste consistencies. Unit can handle press-in, screw and crimp closures, spray pumps with dip tubes, measuring cups, etc.
Optima...
Hygienic tube and pipe hangers save time during installation.(Exhibitor Preview)
March 1, 2005... Hangers incorporate several installation time-saving benefits. The swivel connection allows the clamps bodies to self adjust, independent of the hanging rod, to the tube's slope. This reduces internal stress on the tube and eliminates tension...
Sanitary pressure transmitters meet 3A criteria.(Exhibitor Preview)
March 1, 2005... The Type S-10.3A and SA-11 sanitary pressure transmitters meet 3A criteria, making them ideal for the pharmaceutical industry. The Type S-10.3A features a 4-20 mA 2-wire signal with other options available. The SA-II offers vacuum, compound and...
Sterile wipers are gamma irradiated and validated sterile.(Exhibitor Preview)
March 1, 2005... Gamma Wipe sterile wipers are gamma irradiated and validated sterile to a SAL of [10.sup.-6] in accordance with ANSI/AAMI/ISO American National Standards and European Standards EN 1174 and EN552.
Berkshire Corp., Great Barrington, MA 01230....
Vessel repair and modification service reduces downtime.(Exhibitor Preview)
March 1, 2005... Company provides on-site CIP testing, vessel evaluation, leak repair, heat transfer surface repair, spot electropolish, refinish vessel interior, and in-house modifications.
Central States Industrial, Springfield, MO 65803. Call...
Casing drain eliminates "dead-leg".(Exhibitor Preview)
March 1, 2005... True zero dead-leg casing eliminates product "dead leg" in centrifugal pump casings. Machining of a diaphragm valve body directly into the pump casing allows for the diaphragm face to be flush with the interior contour of the pump.
...
Condensate pump designed for long life.(Exhibitor Preview)
March 1, 2005... The Pivotrol[R] is engineered for dependable steam system condensate recovery in rapid-cycling process environments and under all pressure and temperature conditions. Pump is designed as a solution to excessive maintenance and energy...
Humidity transmitter designed for demanding application.(Exhibitor Preview)
March 1, 2005... The HUMICAP[R] Humidity and Temperature Transmitter Series HMT330 is developed for demanding industrial applications where stable measurement and wide customization possibilities are important.
Vaisala Inc., Woburn, MA 01801. Call...
Tablet coating system ideal for aqueous, solvent and sugar coating.(Exhibitor Preview)
March 1, 2005... The VPC series of Hi--Coaters feature a fully perforated coating drum system for the application of aqueous, solvent and sugar film coatings. Full size access doors on each side and the front of the unit allows for easy access to the pan...
Oxygen monitoring system is non-invasive.(Exhibitor Preview)
March 1, 2005... The DOOPT is a fiber optic-based dissolved oxygen monitoring system that is non-invasive, reliable and fast. It allows the real-time measurement of dissolved oxygen concentration inside the Cellbag[R] bioreactors. Mini fiber optic oxygen...
Modular units produce pure water.(Exhibitor Preview)
March 1, 2005... The ORION TTS features total thermal sanitization of the entire water treatment plant, from inlet to outlet, at over 80[degrees]C. Hot water sanitization of the complete system, including the--treatment filters and softeners, enables easy...
Metal detector improves product purity.(Exhibitor Preview)
March 1, 2005... The E-Z Tec[R] improves process purity through detection of minute metal contaminants during the production of any capsule or tablet-based product. Electronic design simplifies setup, ensures reliable operation, provides instantaneous recovery...
Laser tablet drilling system ideal for controlled release drug delivery.(Exhibitor Preview)
March 1, 2005... The CMS non-contact laser drilling process can exceed 100,000 tablets per hour--with computer controlled flexibility of the hole pattern, diameter, depth, and tablet side(s) to be drilled.
Control Micro Systems, Inc., Winter Park, FL,...
Inspection system features parallel laser measurement accuracy.(Exhibitor Preview)
March 1, 2005... The Ca-Zoom[R] PTZ6.0 remote video inspection system now features a Parallel Laser Measurement accessory, which can be installed on the PTZ140 or PTZ100 camera head.
Everest VIT, Flanders, NJ 07836. Call 973-448-0077 Booth No. 1588
...
Ceiling mounted enclosure prevents fluid collection.(Exhibitor Preview)
March 1, 2005... The Type 4X ceiling-mount enclosure features a cover design that won't trap fluids, preventing splashing and dripping. The enclosure can be used in place of standard industrial enclosures which have a formed flange that can collect washdown...
Two wire controls for high purity valves.(Exhibitor Preview)
March 1, 2005... CleanFlow high purity ball valves are used in high purity and clean steam systems throughout the pharmaceutical industry. To meet today's requirements for Two-Wire control, company now offers their "Device-ID" program.
SVF Flow Controls,...
Doorway barrier retains spills.(Exhibitor Preview)
March 1, 2005... Automatic doorway spill barrier system controls spills or sprinkler releases by containing the spill inside the effected area and away from sewer and storm drains, eliminating the need for extensive trench drains and containment ponds.
...
Urethane flooring systems withstand chemical attacks.(Exhibitor Preview)
March 1, 2005... Poly-Crete HF, and Poly-Crete KT are formulated to withstand aggressive thermal and chemical attacks, resist abrasion, and are easy to maintain. Both systems provide exceptional durability and service.
Dur-A-Flex, Inc., East Hartford, CT...
Precision-made hygienic clamps for sanitary connections.(Exhibitor Preview)
March 1, 2005... Hygienic clamps are made specifically for the pharmaceutical/biotech industries where joint cleanliness and efficiency are of paramount importance. Stainless steel clamps are made from investment castings to produce a high quality, precision...
Drug delivery devices help increase patient compliance.(Exhibitor Preview)
March 1, 2005... Topical drug delivery devices include the Steripen for metered-dose topical spot-treatment; the Valve-Tube for high volume requirements; and the INTACT Cartridge System which is the core of metered dose devices.
Med-Instill, Stamford, CT...
CIP System makes cleaning easier.(Exhibitor Preview)
March 1, 2005... The portable Ultra Flow CIP System makes difficult cleaning situations much easier. It provides great flexibility in one package. Rinsing with a low volume fresh water supply is no problem because the Ultra Flow can rinse by dilution.
...
Filters/bag assemblies available from stock.(Exhibitor Preview)
March 1, 2005... Company now offers the Gammasart Biosystem SA line of standard presterilized filter and bag assemblies. Gammasart Biosystem SA's are in stock, eliminating the lead-time and complications of coordinating a custom designed filter and bag...
Pressure-sensitive labeler can handle a wide range of containers.(Exhibitor Preview)
March 1, 2005... The servo-driven, in-line Auto-Colt III pressure sensitive labeler handles round, oval, square and rectangular containers from 1 to 14 inches in height and from 5/8 to 7 inches in diameter at speeds up to 250 cpm.
NJM/CLI, Lebanon, NH...
Flooring line consists of three types.(Exhibitor Preview)
March 1, 2005... Flooring consists of three types of flooring technology--methylmethacrylate (MMA), cementitious urethane and epoxy. Taking just one hour to fully cure, MMA flooring can reduce down time in pharmaceutical processing plants, thereby reducing...
Facility ID assessment can improve safety and productivity.(Exhibitor Preview)
March 1, 2005... The ID Services Group will send trained professionals to assess and analyze your facility's needs, including a plant walk down and interviews with key plant personnel.
Brady Corporation, Milwaukee, WI 53223. Call 800-643-8766.
Booth...
Sterilizer provides precise monitoring.(Exhibitor Preview)
March 1, 2005... The Minidox-M chlorine dioxide gas sterilization system provides a rapid and highly effective method to decontaminate isolators, rooms, processing equipment, and pass-throughs as well as to sterilize products or components.
ClorDiSys...
Wall panels ideal for lab applications.(Exhibitor Preview)
March 1, 2005... Stainless steel and high impact Acrovyn[R] wall panels are ideal for lab applications due to their cleanability, durability and UL Class 1 Fire Rating. Panels have a moisture resistant vapor barrier on their backside to prevent curling.
...
Conveyors feature tool-free dismantling.(Exhibitor Preview)
March 1, 2005... The fully-pneumatic, UC Series features a unique unibody construction for tool-free dismantling and easy cleaning. Conveyors are extremely hygienic, making them ideal for a variety of applications, including loading and unloading coating pans,...
Door meets cleanability needs.(Exhibitor Preview)
March 1, 2005... The Pharma-Seal door is engineered to meet the cleanability and seal needs of the pharmaceutical industry. This fully enclosed door offers stainless steel on the inside and the outside.
Rytec Corporation, Jackson, WI 53037. Call...
Multi-bucket system is autoclavable.(Exhibitor Preview)
March 1, 2005... Multiple bucket system features a fully autoclavable cart that easily expands to accommodate up to three buckets, allowing for differentiation between solvent/disinfectant and rinse water. Ideal for use in sterile environments.
Contec,...
Data logger/digital transmitter offers a large range of features.(Exhibitor Preview)
March 1, 2005... The HygroLog[R] NT data logger/digital transmitter features: HygroClip[R] digital humidity technology; FDA CFR 21 part 11 and GAMP 4 compliant software; and compact flash memory card for virtually unlimited logging capacity.
Rotronic...
Industrial vacuum cleaners feature clog resistant filters.(Exhibitor Preview)
March 1, 2005... The CFM 08 Series of industrial vacuum cleaners feature clog-resistant filters and interchangeable attachments for fast, continuous cleaning, and quiet-running motors and cord holders for safe operation.
Nilfisk-Advance America, Malvern,...
Engineering and consulting services.(Exhibitor Preview)
March 1, 2005... A vertically integrated family of firms, company offers consulting engineering and scientific investigations, laboratory analysis, manufacturing, construction management, and contract operations and maintenance services.
O'Brien & Gere...
UV absorption sensor features two channels.(Exhibitor Preview)
March 1, 2005... The AF46 dual wavelength UV absorption sensor features two discrete measurement channels, each with separate wavelengths. This allows a differential measurement that provides superior baseline stability and background noise rejection.
...