Pharmaceutical Processing articles from April 2005

Pharmaceutical Processing archives from April 2005

Close to home.(From the Editor)
April 1, 2005... My father-in-law, a robust man in his early 60's was recently diagnosed with Mesothelioma Mesothelioma is a cancer that orginates in the mesothelium tissues, the part of the body that holds different organs in place. The mesothelium protects...

Stainless steel cleanroom tables provide clean, durable surface.(What's Hot)
April 1, 2005... Series 62 Cleanroom Stainless Steel Tables are ideal for cleanrooms of Class 100,000 to Class 10. The stainless steel will not crack, chip, corrode or generate particulates, and is ideal in applications where heavier loads or impact would cause...

Leak tester uses vacuum to detect leaks.(What's Hot)
April 1, 2005... The compact BLI machine is fed by stacking the blister packs via a pick and place mechanism inserted in a testing chamber. Special sensors analyze the swelling of each blister cell when under vacuum. Faulty blisters are rejected. The BLI...

Contract packaging services includes clinical trial kit production.(What's Hot)
April 1, 2005... Company has broadened their range of capabilities by adding clinical trial kit production and physician sample kit services, including sourcing, fulfillment, packaging and distribution. Company recently moved into a new, climate-controlled...

Horizontal form, fill, seal machine designed specifically for the pharmaceutical industry.(What's Hot)
April 1, 2005... The INTEGRI-SEAL horizontal form, fill and seal machine is designed to produce 4-sided seal packages with secure, sterile seals for such items as wound dressings, sterile fields swab sticks, catheters, syringes, and sutures. Units feature a...

Autoclavable lab fermentors and bioreactors designed for R & D.(What's Hot)
April 1, 2005... The BIOSTAT[R] B Plus Twin can accommodate two autoclavable culture vessels with a choice of 1L to 10L working volumes. The integrated system concept includes a stainless steel cabinet housing the control, thermostat, aeration, and stirrer...

Isolator designed for automated parenteral filling machines.(What's Hot)
April 1, 2005... This totally contained vial or syringe filling isolator is designed for automated parenteral filling machines. Ergonomic integration of any of several available filler platforms with this technology provides easy aseptic loading, off-loading...

Interchangeable turret tablet press offers quick parts remove and change-over.(What's Hot)
April 1, 2005... The Hata CVX features removable turret technology combined with an easy to clean design for quick parts removal and change-over. Unit also utilizes a reduced number of interior parts and less weight on heavier press components. Press is...

Lab-sized freeze dryers available in several sizes.(What's Hot)
April 1, 2005... Laboratory sized freeze-dryers are available in sizes from bench-top 3.5 liter manifold units with microprocessor controls to stoppering units with 10 square foot shelf space and PC/PLC control. The advanced research model offers control...

Checkweighers offers a greater range of options.(What's Hot)
April 1, 2005... The GP-Pharma, with a product weight capacity of 500g, has been developed to bridge the gap between the general purpose product lines and the high-end Rx weigher. With the same weighing technology as used in the high-end Rx, the GP-Pharma...

Bulk bag conditioning system available in several styles.(Processing Components)
April 1, 2005... Material Master bulk bag conditions are available with two hydraulically actuated "compression" plates mounted on opposing sides that break up material which has hardened or developed lumps inside bulk bags during transit and/or storage. System...

Vibratory feeders/conveyors transport materials efficiently.(Processing Components)
April 1, 2005... The Model HVF--High Volume Feeder is a two-mass vibrating system, spring coupled and excited by a motor-driven eccentric shaft. Adjustable-angle rubber springs transmit the exciting force and can "fine tune" the motion of the trough to optimize...

Wet Drum Separators increase product purity and productivity.(Cool Technology)
April 1, 2005... Wet Drum Separators remove contaminants from the product stream, increasing product purity and plant productivity. The separators can reduce interrupted production runs and costly wear on production machinery. In addition the separators are now...

Bioprocess membrane separation system available in two versions.(Cool Technology)
April 1, 2005... The UniFlux is available in a fully-automated system, powered by UNICORN software and designed to control and respond to process events; and the Windows based PC data logging version for scientists and engineers who prefer hands-on control. ...

Filter cleaning system keeps filters operating efficiently.(Cool Technology)
April 1, 2005... TEKRINSE screen-cleaning technology allows TEKLEEN filters to use less than two gallons of water per backwash cycle. The main flow remains uninterrupted, allowing operations to continue smoothly. The only requirement for automatic,...

Benchtop centrifuge offers a wide array of rotors.(Cool Technology)
April 1, 2005... The Universal 32/32R benchtop centrifuge utilizes one of the widest arrays of rotor selections and affords the user the ability to process a multitude of tubes, from microlitre tubes to 100mL bottles to microtitre plates. Utilizing its...

Liquid handling system optimizes protein concentration and protein washing applications.(Cool Technology)
April 1, 2005... The SciPure TFF System automates, optimizes and documents protein concentration and protein washing applications. SciPure's patented technology includes on-board software and hardware providing constant TMP and constant flow rate--regardless of...

Filter/dryer can be used for wet or dry processes.(Cool Technology)
April 1, 2005... The PharmASep family of filter/dryer machines combines the company's patented Vibro-Energy[R] separation with Vibro-Dry vacuum drying technology to filter and dry product efficiently and effective[y while significantly increasing convenience,...

Disposable filtration systems are easy to use and reduce cleaning requirements.(Cool Technology)
April 1, 2005... Systems provide increased security, while saving time and money. Security is increased since disposable systems are used once and discarded, so the risk of cross contamination is eliminated. Time is saved since the disposable units can be used...

Cold sterilant available in kit form.(Cool Technology)
April 1, 2005... Minncare[R] Cold Sterilant is available in a kit form for the disinfection of small, bench top water treatment systems and capsule filters. The kits contain a small container of Minncare Test Strips to measure for correct concentration of...

PAT initiative expected to invigorate pharmaceutical industry.(Cover Story)
April 1, 2005... Pharmaceutical manufacturers are facing some of the most challenging market conditions ever. Better and improved technologies are available, but companies find themselves under increased pressure to bolster drug pipelines, accelerate the...

Vibration meter troubleshoots and quantifies very small or large levels of vibration.(QA/QC Equipment)
April 1, 2005... The Model 205 features sensitivity as low as 0.04 mils and a very wide frequency range of .4 to 5000 Hz making it ideal for very slow and very fast processing speeds. The unit features a small, lightweight 100 mV/g accelerometer that is...

Metal detector features user-friendly interface.(QA/QC Equipment)
April 1, 2005... The E-Z Tec[R] DSP features state-of-the-art electronic design that combines an easy-to-use 40 x 50 touch screen interface with advanced digital signal processing to provide detailed analysis and reporting. The unit features a high level of...

The benefits of monitoring carbon dioxide and oxygen in pharmaceutical fermentation processes.(Applications)
April 1, 2005... Fermentation is commonly used for a variety of pharmaceutical production processes, such as the production of recombinant therapeutic proteins in yeast and the bio-transformation of chemical drug intermediates to reduce the feedstock to the...

Industry buzz ... and best practices at Interphex2005.(Interphex2005 Update)
April 1, 2005... Pharmaceutical manufacturers are under pressure as never before--not only from regulators, but also from the medical establishment, government, investors and consumers. New challenges are emerging everywhere, and many solutions are still...

Manual batching systems offer flexibility and low costs.(Material Handling)
April 1, 2005... Systems are modular, and are tailored to the user's production requirements. Components include material silos, high-efficiency unloaders, and integrated dust collection. Dispenser has patented design features which eliminates "bridging" a...

Storage/retrieval system stores up to 40 million samples.(Material Handling)
April 1, 2005... The MatriStore provides a compact approach to meeting storage needs for pharmaceutical labs. The modular system design offers shortened installation times, reduced overall costs, and the option to grow as storage needs grow. System has the...

2005 Facility of the Year Award finalists.(2005 Facility of the Year Awards)
April 1, 2005... ISPE, INTERPHEX, and Pharmaceutical Processing are proud to announce the five finalists for the inaugural 2005 Facility of the Year Award competition, celebrating excellence in pharmaceutical or biopharmaceutical facility design, engineering,...

Pharmaceutical processing in controlled atmosphere environments: new instrumentation offers precise methods for controlling and monitoring critical processing and research workspaces.(Applications)
April 1, 2005... Control and monitoring of critical environments at production and research areas usually involves parameters of pressure, temperature, humidity, and airflow--individually or in combination. However, to achieve and maintain a critical...

Shut-off valve designed for high backpressure/vacuum.(Processing Components)
April 1, 2005... Series BSR 1/2" air operated shut-off valves feature no wetted metals or external fasteners for high-purity or corrosive environments. These balanced, compact valves are designed for liquid services ranging from full vacuum to pressures up to...

Boilers available with passivated pressure vessel.(Processing Components)
April 1, 2005... The Series SSB is designed to produce clean, efficient steam up to 100 psig in a range from 36pph to 540 pph. Units operate on electricity, can be locates almost anywhere and are compatible for use with distilled, demineralized, deionized or...

Prescription for magnetic separation in the pharmaceutical industry.(Applications)
April 1, 2005... New developments in magnetic separation technology offer highly effective and efficient methods for magnetically cleaning pharmaceutical feedstocks. Today's innovative magnet materials and circuit design methodology enable the production of...

Pure-Fit[R] SIB[R] smooth inner bore systems.(Advertisement)
April 1, 2005... NEW! The Pure-Fit[R] SIB[R] (smooth inner bore fitting system provides a seamless transition in critical biopharmaceutical applications. A unique, one-piece assembly manufactured from high-purity materials, features our innovative smooth...

Flexible components TLCTCO series hose.(Advertisement)
April 1, 2005... TLCTCO provides the flexibility you need and the inner-core smoothness you demand for pharmaceutical transfer and processing needs. Super smooth inner tube made of Chemfluor[R] FEP fluoropolymer reinforced with externally convoluted EPDM rubber...

Flexible components TLCT series hose.(Advertisement)
April 1, 2005... Made of Chemfluor[R] FEP fluoropolymer for its inner tube and reinforced with EPDM rubber cover, TLCT has won its name recognition by its super smooth inner tube that is ideal for pharmaceutical processing and transfer. TLCT is highly chemical...

Pure-Fit[R] FGR series hose.(Advertisement)
April 1, 2005... Super flexible and light weight, Purefit[R] FGR rubber hose is the choice in the pharmaceutical industry for washdown applications. Made of light grey EPDM cover and white nitrile-PVC blend inner tube, Purefit[R] FGR hose has a smooth inner...

Pure-Fit[R] TC tube clamp systems.(Advertisement)
April 1, 2005... NEW! The first in a new generation of clamping systems, the Pure-Fit[R] TC tube clamp system provides complete fluid stoppage with just one hand. Pure-Fit[R] TC features a smooth outer body with no sharp edges or corners, protecting...

SaniPure[TM] BDF tubing[TM].(Advertisement)
April 1, 2005... NEW! SaniPure[TM] BDF[TM] is a Biopharmaceutical-grade tubing certified to be free of animal material and derivatives. SaniPure[TM] BDF[TM] is fully characterized in accordance with biological, chemical, and physical guidelines, including...

Use of excipient economics can significantly improve process efficiency.(Solutions)
April 1, 2005... In recent years, mounting pressures in the pharmaceutical industry to lower drug costs have required pharmaceutical companies to more aggressively examine their drug development and manufacturing processes to improve time and cost efficiencies....

Heavy-duty enclosures reduce blower noise.(Processing Components)
April 1, 2005... Sound enclosures are extremely effective in reducing noise levels up to 20 dB(A). They feature a compact design with lockable, wide-opening maintenance doors and provide easy access for oil checks and changes, filter checks and v-belt...

Mini proportional control valve offers high flow capabilities.(Processing Components)
April 1, 2005... Available in various pressure ranges up to 116 PSI, the VP12 is ideal for applications that require a compact solution due to limited installation space. With an operating temperature range of 32 to 140F and IP30 weatherproof protection the...

Novo Nordisk A/S--the NovoSeven[R] facility, Kalundborg, Denmark.(2005 Facility of the Year Awards)
April 1, 2005... Facility Considerations Due to an urgent demand for the hemophilia drug, NovoSeven[R], the project design for the new 14,000 square-meter NovoSeven[R] manufacturing facility, ordered by Novo Nordisk A/S, was driven by the requirement to...

Undercounter washers feature design simplicity.(Laboratory Equipment)
April 1, 2005... Washers feature easy loading and a user-friendly interface. With an upper rack clearance of 10.25" and lower rack clearance of 12.75", the washer can handle most baskets in any combination. Spindle-ready models can accommodate either 1 or 2...

Enclosures provide a controlled environment.(Laboratory Equipment)
April 1, 2005... Purifier[R] Filtered PCR Enclosures provide a controlled environment to perform polymerase chain reaction experiments. During operation, room air is drawn through a pre-filter in the top of the cabinet to trap large particles. Then, the air...

Coding/labeling systems include systems, software, supplies and services.(Production Equipment)
April 1, 2005... Markem and LSI have joined to offer integrated coding and labeling solutions. LSI labelers easily integrate with Markem products such as SmartDate[R] thermal transfer coders and SmartLase laser coders. The LSI Series 1500 bottle wrap labeler is...

Pump tanks available in stainless steel for long life.(Production Equipment)
April 1, 2005... Double-welded pump tanks are available in either stainless steel or epoxy-coated carbon steel construction for long-life, corrosion-resistant performance. The tanks feature high-efficiency, close-coupled, non-overloading centrifugal pumps...

Custom engineered process engineering and automation.(Show Capsules)
April 1, 2005... Booth No. 1863 Company offers process engineering and automation combined with custom stainless steel fabrication and field installation services. Services include electrical engineering, high-purity fabrication, project management and...

Bottom mounted mixers are magnetically coupled.(Show Capsules)
April 1, 2005... Booth No. 1615 Full line of magnetically coupled bottom mounted mixers are capable of mixing volumes as low as 5 liters and as large as 30,000 liters. The Upstream Mixer, can mix high volumes of buffers and difficult to wet powders by...

Cabinets designed for IBC tote storage.(Show Capsules)
April 1, 2005... Booth No. 3144 Custom engineered, non-occupancy cabinets provide safe and compliant tote storage. The FM Approved designs allow for both single and double sided access to the cabinet and can accommodate anywhere from 2 to 24 rotes. Sump...

Molded silicone components ideal for various containers.(Show Capsules)
April 1, 2005... Booth No. 1637 Stoppers and sealing systems for carboys and vessels, bottles, laboratory equipment, and process and storage containers are clean room manufactured from Class VI, platinum-cured silicone. The components offer smooth,...

Vial storage trays feature separate lockable covers.(Show Capsules)
April 1, 2005... Booth No. 2857 Vial storage trays feature unique patent pending gate design coupled with separate lockable covers. The design creates a secure storage and transport system for vials and ampoules. Polycarbonate material eliminates...

Nozzle helps eliminate clogging.(Show Capsules)
April 1, 2005... Booth No. 2463 The PJ Nozzle with porous polypropylene filters helps to eliminate clogging in small impingement nozzles. These filters offer greater surface area, thereby reducing the frequency with which nozzles need cleaning Design...

Sterile wipers are gamma irradiated and validated sterile.(Show Capsules)
April 1, 2005... Booth No. C157 Gamma Wipe sterile wipers are gamma irradiated and validated sterile to a SAL of [10.sup.-6] in accordance with ANSI/AAMI/ISO American National Standards and European Standards EN1174 and EN552. Wipers are designed for...

Sterile Visual Flow indicators are FDA compliant and 3-A approved.(Show Capsules)
April 1, 2005... Booth No. 747 Designed to be mounted in-line for high purity applications, the new 4-window Sterile Visual Flow indicators have been redesigned to minimize bacteria traps using a unique o-ring design and precision-bore glass. O-rings meet...

Silicone hose improvements increase flexibility and strength.(Show Capsules)
April 1, 2005... Booth No. 1637 Reinforced silicone hoses, APSM and APSW, are made from platinum-cured, Class VI silicone and offer multi-ply mandrel-wrapped fabric for reinforcement. APSW also contains steel reinforcing wire for added pressure and vacuum...

Aseptic bag filling service available with line of custom bags.(Show Capsules)
April 1, 2005... Booth No. C355 Company now offers aseptic gag filling to compliment its complete line of customer bags and disposables for use in pharmaceutical manufacturing The machine is capable of filling from 100 ml to 20 liter bag sizes, with less...

Combined process technologies assist with PAT.(Show Capsules)
April 1, 2005... Booth No. 1855 Targeted at meeting PAT objectives, company bas combined their blending, fluid-bed, granulating and coating process technologies with the appropriate analytical techniques. L. B. Bohle LLC, Warminster, PA 18974. Call...

Clean Sweep mixer uses swinging motion.(Show Capsules)
April 1, 2005... Booth No. 1119 The Clean Sweep mixer uses a swinging motion instead of the customary rotating motion. It provides a hermetically sealed environment--no rotating shaft seal--and is ideal for low-shear, high purity mixing applications. ...

Syringe packager checks for needle protection device.(Show Capsules)
April 1, 2005... Booth No. 1855 The Corima AEC218 is designed for packaging disposable syringes. After automatically loading the syringes, the machine checks for the presence of the needle protection device, inserts the plunger, prints the appropriate...

Weigh scale modules feature reduced installation time.(Show Capsules)
April 1, 2005... Booth No. RP-4. The single-scale HI 1769-WS and dual-scale HI 1769-2WS weigh modules read weight and diagnostic data from one or two scales, communicating it to Allen-Bradley[R] MicroLogix 1500 and CompactLogix controllers. Both modules...

Form/fill/seal machine ideal for small product and batch runs.(Show Capsules)
April 1, 2005... Booth No. 2655 The R140 rollstock machine is fully automatic, space saving, and is ideal for small product and batch runs. A range of medical and pharmaceutical packaging samples will also be on display. Multivac Inc., Kansas City, MO...

Automated particle analysis system identifies foreign particles in powders.(Show Capsules)
April 1, 2005... Booth No. C108 The ASPEX Rx is designed for automated analysis of particles under 10 microns. It is used by leading pharmaceutical companies to identify, size, and elementally classify foreign particles in applications that are beyond the...

Feeders and vacuum conveyors available in various configurations.(Show Capsules)
April 1, 2005... Booth No. 2055 The Micro Feeder Model MT12 is a loss-in-weight feeder that uses an optional draft shield, often used when weighing at very low rates. K-Tron Feeder Group, Pitman, NJ 08071. Call 856-589-0500. InfoLINK Enter...

Pinhole Inspector checks for liquid leakage.(Show Capsules)
April 1, 2005... Booth No. 1763 The HDI Series Pinhole Inspector is designed to inspect blow-fill-seal containers for liquid leakage in either strip form or individual containers. The compact design is easily integrated into any production line for 100%...

Drainable angle fittings enhance draining, cleaning of biopharm process systems.(Show Capsules)
April 1, 2005... Booth No. 1363 Swagelok[R]88[degrees] and 92[degrees] drainable angle fittings provide smooth flow and help you configure easy to drain and clean biopharm process systems. Available in sizes from 1/2 through 4 in., elbow fittings have...

Mid-scale capsule filters designed for biopharmaceutical processors.(Show Capsules)
April 1, 2005... Booth No. 1555 MidiCaps are being introduced to replace the company's original 500, 1000, 2000 & 4,500 [cm.sup.2] capsule filters. New features include: laser imprinted labelling; improved vent design; updated connection styles; and...

Filling system handles pre-sterilized stoppers.(Show Capsules)
April 1, 2005... Booth No 1074 The P1540 automated filling system handles pre-sterilized stoppered vials. Ideal for pilot plants, R&D facilities and biotech companies looking to automate small-scale liquid filling operations, the P1540 improves labor...

Modular fermentation systems feature sterile integrity and dependable operation.(Show Capsules)
April 1, 2005... Booth No. 1537 The GEA Diessel series of modular fermentation systems automatically maintain temperature, pH, agitator speed, etc. and have several options for nutrient feed and oxygen dispersion. Systems are equipped with an open...

Continuous coater offers adjustable pan volumes.(Show Capsules)
April 1, 2005... Booth No. 1835 The CC3015 integrates adjustable pan volumes via a modulating discharge weir; 4 variable inlet air zones; 6 staged spray zones with anti-bearding nozzles and water tight construction. O'Hara Technologies Inc., Richmond...

Closure Processing System maintains sterility.(Show Capsules)
April 1, 2005... Booth No. 1137 The Advanced Closure Processing System (CPS) washes, rinses, siliconizes, sterilizes, dries and delivers rubber stoppers--and other closures--in an unbroken sterile chain. Using "bubble power," closures in the transfer...

Tablet press offers centrifugal die filling.(Show Capsules)
April 1, 2005... Booth No. 1237 The IMA COMPRIMA 300 tablet press features centrifugal die filling guaranteeing yields up to 99.5% and improving powder feeding: maximum production speeds are possible even with oblong or shaped tablets. The long compression...

Microbiology System assists with PAT.(Show Capsules)
April 1, 2005... Booth No. 1741 The PALLCHEK is the first Rapid Microbiology System, based on ATP bioluminescence, that bas successfully and completely met the necessary requirements needed for getting FDA approval under the PAT initiative. Pall Corp.,...

Data logger/transmitter offers large range of features.(Show Capsules)
April 1, 2005... Booth No. 2347 The HygroLog NT data logger/digital transmitter features: HygroClip[R] digital humidity technology; FDA CFR 21 part 11 and GAMP 4 compilant software; compact flash memory card for virtually unlimited logging capacity; wide...

Checkweigher delivers extreme accuracy and performance.(Show Capsules)
April 1, 2005... Booth No. 1305 The Starweigh Checkweigher is a starwheel-based checkweigher that maintains high throughput and accuracy while handling a wide range of container sizes. One Starweigh Checkweigher can be changed over to handle containers...

Precision dispensers and metering pumps featured in catalog.(Show Capsules)
April 1, 2005... Booth No. 284 Products include the Model SMTRH, a SubMicroLiter Pump capable of dispenses as low as 500 Nanoliters. Other additions to the line include the STRH which is a Low Flow Stepper Pump ideal where frequent and accurate adjustments...

Sampling device eliminates possibility of false positives.(Show Capsules)
April 1, 2005... Booth No. 1615 The NovaSeptum SV is designed for small volume sampling such as the new RMM (Rapid Microbiological Methods). The unit bas specific features that are ideal for both the new RMM and traditional methods of testing: Small and...

Powered air purifying system offers unobstructed vision.(Show Capsules)
April 1, 2005... Booth No. 721 The RT Hood/PA30 PAPR system offers performance achieving fit factors above 100,000 (2004 RDECOM study), comfort offering unobstructed visibility without requiring a head band, and advanced NiMH battery technology and longer...

In-Line Oxygen Detection System monitors container headspace.(Show Capsules)
April 1, 2005... Booth No. 2476 The VISTA/O In-Line Oxygen Detection System monitors oxygen in the headspace of sterile product containers. Lighthouse Instruments, LLC, Charlottesville, VA 22902. Call 434-293-3081. InfoLINK Enter 006-50401-165 at...

Powder transfer coupling achieves nanogram level containment.(Show Capsules)
April 1, 2005... Booth No. 2173 The 10" ChargePoint high containment powder transfer coupling will be on display. Also featured will be an array of ChargePoints including the PSL Vortex ChargePoint System which achieves nanogram level containment and the...

Heat transfer fluids lower outlet temperatures.(Show Capsules)
April 1, 2005... Booth No. C172 Simply changing out a low-temperature silicone fluid with new Paratherm CR heat transfer fluid will lower heat-exchanger outlet temperature by 10[degrees]C. Also featured: Paratherm LR Heat Transfer Fluid, a non-aqueous,...

High purity ball valve easily automated.(Show Capsules)
April 1, 2005... Booth No. 2749 The model SB7F features self-aligning interlocking ends and the company's exclusive "fine adjust" handle to ensure exact alignment of the entire flow path. SVF Flow Controls, Inc., Santa Fe Springs, CA 90670. Call...

Hangers reduce installation time and simplify slope adjustments.(Show Capsules)
April 1, 2005... Booth No. 2089 The "RH Series" hangers reduce installation rime and simplify the slope adjusting and verification processes. The housing's ability to self adjust to the slope combined with the telescopic feature allow for tuning...

Full containment water washable tablet press.(Show Capsules)
April 1, 2005... Booth No. 1081 The Aquarius III is a full containment tablet press. It offers the option of tabletting in a vacuum, completely isolating it from the compression room. In addition to "Vacuum Tabletting", Aquarius has Wash in Place and Clean...

Sampling and transfer assemblies.(Show Capsules)
April 1, 2005... Booth No. 1677 Ame-Collect silicone tube assemblies are used for sterile transfers and aseptic sampling in fermentation, cell culture, and lab applications. Amesil High Purity Polymers, Oak Ridge, NJ 07438. Call 973-697-4100. ...