Journal of the American Statistical Association articles

Recent articles from Journal of the American Statistical Association

A model-based background adjustment for oligonucleotide expression arrays.
December 1, 2004... 1. INTRODUCTION Affymetrix GeneChip arrays are the most popular high-density oligonucleotide expression arrays, used by thousands of researchers worldwide. To probe genes, oligonucleotides of length 25 base pairs (bp) are used. Typically, the mRNA sequence of a gene is represented by a...

Structural mean effects of noncompliance: estimating interaction with baseline prognosis and selection effects.
December 1, 2004... 1. INTRODUCTION Efron and Feldman (1991) brought a new impetus to causal inference with noncompliance in controlled clinical trials. They modeled the mean effect of cholestyramine in a placebo-controlled trial as a linear function of the percentage of assigned cholestyramine that is...

A random pattern-mixture model for longitudinal data with dropouts.
December 1, 2004... 1. INTRODUCTION Many longitudinal studies suffer from attrition, which can cause bias in the analysis if the dropouts are informative. To account for informative dropout, a number of model-based approaches have been proposed to jointly model the longitudinal outcome and the dropout...

Improved semiparametric time series models of air pollution and mortality.
December 1, 2004... 1. INTRODUCTION Estimation of adverse health effects associated with ambient exposure to particulate matter (PM) constitutes one of the most interesting recent case studies on the use of epidemiologic evidence in public policy (Samet 2000; Greenbaum et al. 2001). Under the Clean Air Act...

Location-scale depth.
December 1, 2004... 1. INTRODUCTION This article proposes a notion of depth in the univariate location-scale model and its possible applications. The new depth is introduced in Section 3 as an instance of the general theory of halfspace depth elaborated by Mizera (2002), based on the idea outlined by...