Journal of Drugs in Dermatology articles from September 2007

Journal of Drugs in Dermatology archives from September 2007

Common and alternate oral antibiotic therapies for acne vulgaris: a review.
September 1, 2007... Abstract Acne vulgaris is an extremely common disorder affecting many adolescents and adults throughout their lifetimes. The pathogenesis of acne is multifactorial and is thought to involve excess sebum, follicular hyperkeratinization,...

The efficacy and safety of rituximab in refractory pemphigus: a review of case reports.
September 1, 2007... Abstract Rituximab is a chimeric murine-human monoclonal antibody that targets the CD20 antigen found on B cells and results in rapid depletion of this cell population. It is indicated for patients with relapsed or refractory, low-grade or...

Bipolar radiofrequency in the treatment of dermatologic imperfections: clinicopathological and immunohistochemical aspects.(Clinical report)
September 1, 2007... Abstract Background: Rapid progress in the technology for skin rejuvenation has allowed for shorter post-treatment times than ever before. An example of such technology is the radiofrequency (RF) device, which offers nonablative skin...

Long-term safety and efficacy of a unique fixed-dose combination gel of adapalene 0.1% and benzoyl peroxide 2.5% for the treatment of acne vulgaris.(Drug overview)(Clinical report)
September 1, 2007... Abstract Background: A unique, once-daily, fixed-dose combination gel with adapalene 0.1% and benzoyl peroxide (BP) 2.5% has been developed for the treatment of acne vulgaris. Objective: To evaluate the long-term (up to 12 months)...

Pilot study using topical imiquimod 5% cream in the treatment of nodular basal cell carcinoma after initial treatment with curettage.(Clinical report)
September 1, 2007... Abstract Background: Nodular basal cell carcinoma (nBCC) is the most common cutaneous malignancy and studies assessing the use of topical imiquimod 5% cream as a monotherapy in the treatment of nBCC have resulted in less than optimal...

Efficacy of a soy moisturizer in photoaging: a double-blind, vehicle-controlled, 12-week study.(Clinical report)
September 1, 2007... Abstract Serine protease inhibitors (soybean trypsin inhibitor [STI] and Bowman-Birk protease inhibitor [BBI]) found in soybeans have been shown to inhibit melanosome phagocytosis by keratinocytes via protease-activated receptor 2 (PAR-2)....

Comparison of pre and/or postphotodynamic therapy and intense pulsed light treatment protocols for the reduction of postprocedure-associated symptoms and enhancement of therapeutic efficacy.
September 1, 2007... Abstract Photodynamic therapy (PDT) and intense pulsed light therapy (IPL) are commonly used in the setting of photorejuve-nation. Patient expectations for minimal to no downtime associated with these procedures has become an increasingly...

Mohs micrographic surgery for an unusual case of keratoacanthoma arising from a longstanding tattoo.(CASE REPORTS)(Case study)
September 1, 2007... Abstract This case report seeks to alert the reader to the possibility that the keratoacanthoma (KA) may develop in tattoo sites, specifically in red tattoo sites. We further wish to describe the senior author's treatment of such a lesion...

Red scrotal syndrome: a localized phenotypical expression of erythromelalgia.(CASE REPORTS)(Case study)
September 1, 2007... Abstract We report a case of red scrotal syndrome responding to oral gabapentin, a neuropathic mediator that is commonly used in the treatment of primary erythromelalgia. The positive response to oral gabapentin and the resemblance of...

Acquired kinking of the hair caused by acitretin.(CASE REPORTS)(Case study)
September 1, 2007... Abstract Alopecia, hypertrichosis, and hirsutism may be caused by a variety of medications. Drug-induced alterations in the texture or structure of the hair shaft, however, are much less common. We report a female patient who presented...

Rebound of psoriasis after efalizumab discontinuation, despite being on high-dose cyclosporine.(CASE REPORTS)(Case study)
September 1, 2007... Abstract Psoriasis rebound after efalizumab discontinuation is well-documented in the literature. We report the case of a patient who experienced psoriasis rebound 2 months after efalizumab discontinuation, despite being on more than 5...

Alopecia universalis: hair growth following initiation of simvastatin and ezetimibe therapy.(CASE REPORTS)(Case study)
September 1, 2007... Abstract Alopecia areata is an organ specific autoimmune disease in which hair is lost in various patterns. Its most extreme form, alopecia universalis, is the total loss of all scalp and body hair. This form of the condition is very...

No nonsense dermoscopy: self-assessment.
September 1, 2007... Introduction Dermoscopy is the standard of care in many countries around the world and has been steadily gaining popularity in the US. As a proponent and teacher of the technique for many years, it has been my hope that it becomes the...

Updates & perspectives on management of common dermatologic disorders.(LIT REVIEW)
September 1, 2007... Acne Vulgaris Tretinoin 0.025%/Clindamycin Phosphate 1.2% Gel: Summary of Available Data A novel aqueous gel formulation, which contains crystalline tretinoin 0.025% and solubilized clindamycin phosphate 1.2%, has been evaluated in 3...

Upcoming dermatology meetings.(Brief article)(Calendar)
September 1, 2007... Domestic 9/27-30 Women's and Pediatric Dermatology Seminar Grand Hyatt San Francisco, San Francisco, CA www.sdefderm.com 10/11-14 American Society for Dermatologic Surgery Sheraton Hotel & Towers, Chicago, IL ...

Topical devices for atopic dermatitis: what is the data behind these new products?(NEWS, VIEWS, AND REVIEWS)
September 1, 2007... The last 5 years have brought a host of new treatments for dermatitis marketed as devices, rather than drugs, to work as stabilizers of the epidermal barrier. Their active ingredients have been tested independently and they are approved through...

Extina[R] receives FDA approval.(PIPELINE PREVIEWS)(Brief article)
September 1, 2007... Stiefel Laboratories, Inc recently announced that the FDA has granted approval for Extina (ketoconazole) Foam, 2%, for the treatment of seborrheic dermatitis. Extina Foam is formulated with VersaFoam[R] technology and is the first foam...

FDA approval for generic terbinafine tablets and cream.(PIPELINE PREVIEWS)(Brief article)
September 1, 2007... The FDA has granted the first approval for generic versions of the prescription medication Lamisil[R] (terbinafine hydrochloride) manufactured by Novartis Pharmaceuticals. The medication is indicated for the treatment of onychomycosis. The...

New Drug Application for Taclonex Scalp[R] gel.(PIPELINE PREVIEWS)(Brief article)
September 1, 2007... Warner Chilcott and LEO Pharma recently announced that a New Drug Application has been submitted to the FDA for Taclonex Scalp gel. Taclonex Scalp gel contains calcipotriene 0.005% and betamethasone dipropionate 0.064%, the same active...

Phase III study for PurTox[R] botulinum toxin type A.(PIPELINE PREVIEWS)(Brief article)
September 1, 2007... Mentor Corporation recently announced that it has begun initial patient enrollment and treatment in its phase III clinical trial of PurTox. PurTox is a purified botulinum toxin type A that is being studied for its effects on the reduction of...

Oral Rambazole[TM] for moderate to severe psoriasis.(PIPELINE PREVIEWS)(Brief article)
September 1, 2007... Barrier Therapeutics recently announced positive results in its phase II, dose-finding trial for the treatment of moderate to severe psoriasis with Oral Rambazole. Rambazole is a novel retinoic acid metabolism-blocking agent. The 2-mg dose will...

Patch-non-Patch[TM] transdermal drug delivery system.(PIPELINE PREVIEWS)(Brief article)
September 1, 2007... A recent report in the European Journal of Dermatology (Volume 17, Number 4, pages 309-312) describes a new transdermal drug delivery system called Patch-non-Patch. Patch-non-Patch is a monolaminated bioadhesive film that incorporates all the...

VivaGel[TM] trial begins.(PIPELINE PREVIEWS)(Brief article)
September 1, 2007... Starpharma Holdings, Ltd recently has begun a trial in the US to assess the safety and efficacy of its SPL7013 (VivaGel). VivaGel is a vaginal microbicide that has been developed for the prevention of HIV and genital herpes virus infections....

Cyclosporine for vulvar lichen sclerosus.(PIPELINE PREVIEWS)(Brief article)
September 1, 2007... A recent report in the Journal of the American Academy of Dermatology (Volume 57, Number 2, pages 276-278) evaluated the efficacy of oral cyclosporine in refractory vulvar lichen sclerosus. The study enrolled 5 patients with refractory lichen...

A multicenter, randomized, double-blind, parallel-group study to demonstrate the efficacy and safety of adapalene/benzoyl peroxide topical gel in subjects with acne vulgaris.(ACNE)(Brief article)
September 1, 2007... Sponsored by Galderma. The primary objective is to demonstrate the superiority in efficacy and assess the safety of adapalene/benzoyl peroxide topical gel versus 0.1% adapalene topical gel, 2.5% benzoyl peroxide topical gel, and topical gel...

A study of continuous oral contraceptives and doxycycline.(ACNE)(Brief article)
September 1, 2007... Sponsored by Oregon Health and Science University. The purpose of this study is to learn if the study drug, doxycycline, can decrease the amount of unplanned vaginal bleeding that women commonly experience when taking combined oral...

Gefitinib and PEG-interferon alfa-2a in treating patients with unresectable or metastatic skin cancer.(SKIN CANCER)(Brief article)
September 1, 2007... Sponsors and Collaborators: University of California, San Diego and National Cancer Institute (NCI). This phase I/II trial is studying the side effects and best dose of PEG-interferon alfa-2a when given together with gefitinib and to see how...

Topical tazarotene in treating patients with basal cell skin cancer and basal cell nevus syndrome.(SKIN CANCER)(Brief article)
September 1, 2007... Sponsors and Collaborators: University of California, San Francisco and National Cancer Institute (NCI). This phase II trial is studying topical tazarotene to see how well it works in treating patients with basal cell skin cancer and basal cell...

Gefitinib in treating patients who are undergoing surgery and/or radiation therapy for locally advanced or recurrent squamous cell skin cancer.(SKIN CANCER)(Brief article)
September 1, 2007... Sponsors and Collaborators: MD Anderson Cancer Center and National Cancer Institute (NCI). This phase II trial is studying how well gefitinib works in treating patients who are undergoing surgery and/or radiation therapy for locally advanced or...

Study evaluating sirolimus in nonmelanoma skin cancer in kidney transplant recipients.(SKIN CANCER)(Brief article)
September 1, 2007... Sponsored by Wyeth. The purpose of this study is to determine the effect of sirolimus on the prevention of new nonmelanoma skin cancer in kidney transplant recipients. Condition Intervention Phase Graft vs. Host...

ZD1839 (Iressa) for recurrent or metastatic squamous cell carcinoma of the skin.(SKIN CANCER)(Brief article)
September 1, 2007... Sponsors and Collaborators: MD Anderson Cancer Center and AstraZeneca. The purpose of this study is to explore the activity of ZD1839 administered to patients with squamous sell carcinoma of the skin who have locoregional recurrence and/or...

Spectral diagnosis of cutaneous malignancy.(SKIN CANCER)(Brief article)
September 1, 2007... Sponsors and Collaborators: MD Anderson Cancer Center and University of Texas. The purpose of this study is to determine the spectroscopic features of skin lesions in vivo. This study also aims to develop the spectral diagnosis system to...

Complete lymph node dissection or observation in treating patients with localized melanoma and sentinel node metastasis who have undergone sentinel lymphadenectomy.(SKIN CANCER)(Brief article)
September 1, 2007... Sponsors and Collaborators: John Wayne Cancer Institute at Saint John's Health Center and National Cancer Institute (NCI). This randomized phase III trial is studying complete lymph node dissection to see how well it works compared to...

Multicenter selective lymphadenectomy Trial II (MSLT-II).(SKIN CANCER)(Brief article)
September 1, 2007... Sponsors and Collaborators: John Wayne Cancer Institute and National Institutes of Health (NIH). Subjects must be diagnosed with melanoma. All subjects receive sentinel lymphadenectomy. If the subject is sentinel node positive and meets study...

Enhanced safety aesthetic laser system.(PHOTOAGING)(Brief article)
September 1, 2007... Sponsored by Scilex Ltd. The purpose of this study is to determine whether a new laser system provides better safety and efficacy than existing lasers in popular cosmetic procedures such as hair removal, treatment of cosmetically disturbing...

The effect of a controlled daily skin care regimen on retinoic acid tolerance.(PHOTOAGING)(Brief article)
September 1, 2007... Sponsors and Collaborators: University of Michigan and Unilever. In this study, we examine whether a daily skin care regimen comprised of an ultra mild cleanser and an effective moisturizer can help improve tolerance to retinoic acid treatment....

Study to evaluate psoriasis outcomes and safety events in patients with chronic moderate to severe plaque psoriasis (response).(PSORIASIS)(Brief article)
September 1, 2007... Sponsored by Genentech. This is a multicenter, prospective, 5-year surveillance study of approximately 5,000 Raptiva[R]-treated patients and approximately 500 non-Raptiva treated patients (formerly 2,500 comparison patients who were treated...

A study of the safety and effectiveness of CNTO 1275 compared to etanercept for the treatment of moderate to severe plaque psoriasis.(PSORIASIS)(Brief article)
September 1, 2007... Sponsored by Centocor, Inc. The purpose of this research study is to compare the effects (good and/or bad) of CNTO 1275 or etanercept on moderate to severe plaque psoriasis. Condition Intervention Phase Psoriasis...

Efficacy and safety of cyclosporine a microemulsion in maintenance patients with chronic plaque psoriasis.(PSORIASIS)(Brief article)
September 1, 2007... Sponsored by Novartis. The study will evaluate the efficacy of cyclosporine when administered twice a week compared to continuous administration, in patients with chronic plaque psoriasis. Condition Intervention ...

UVA1 light for scleroderma and similar conditions.(FIBROSING DISORDERS)(ultraviolet-A1 )(Brief article)
September 1, 2007... Sponsored by University of Michigan. The purpose of this investigation is to evaluate the effectiveness of high-dose ultraviolet-A1 (UVA1) irradiation in the treatment of fibrosing conditions of the skin such as keloids (thick scars from growth...

Ultraviolet B light therapy in the treatment of skin conditions with altered dermal matrix.(FIBROSING DISORDERS)(Brief article)
September 1, 2007... Sponsored by University of Michigan. This research study will evaluate the effectiveness of high dose ultraviolet B light therapy in the treatment of keloid (or hypertrophic scar), scleroderma, acne keloidalis nuchae, old burn scars, granuloma...

Bioelectric field imaging near human skin wounds.(SKIN INFECTION)(Brief article)
September 1, 2007... Sponsored by National Institute of General Medical Sciences (NIGMS). The investigators have developed a new noninvasive medical device called the Bioelectric Field Imager. They plan to use this device to measure the electric field near small...

Efficacy study of antiseptic preoperative scrubs in prevention of postoperative wound infections.(SKIN INFECTION)(Brief article)
September 1, 2007... Sponsored by Baylor College of Medicine. This trial is to compare the impact of disinfecting the skin with ChloraPrep[R] (2% chlorhexidine and 70% isopropyl alcohol) versus Betadine[R] on the rates of infection of clean-contaminated surgical...

Comparison of cephalexin versus clindamycin for empiric treatment of suspected CA-MRSA skin infections.(SKIN INFECTION)(Brief article)
September 1, 2007... Sponsored by Johns Hopkins University. The purpose of this study is to help define the role of antibiotics in the treatment of pediatric skin infections caused by CA-MRSA. Condition Intervention Phase ...