Journal of Drugs in Dermatology articles from September 2006

Journal of Drugs in Dermatology archives from September 2006

A letter from the Guest Editor.
September 1, 2006... I am very pleased, fortunate, and honored to be the Guest Editor for this special laser edition of the Journal of Drugs in Dermatology (JDD). From its very onset, this journal has provided clinicians with well-written, peer-reviewed manuscripts...

A chemical look at benzoyl peroxide may prove helpful.(LETTERS TO THE EDITOR)(Letter to the editor)
September 1, 2006... Benzoyl peroxide, which is the subject of Dr. Weinberg's recent article (J Drugs Dermatol, 2006;5(4):344-9), is a drug which we have also studied in the lab and in clinical practice. First, I commend Dr. Weinberg for charting actual comparisons...

Etanercept and recalcitrant acrodermatitis continua of Hallopeau.(LETTERS TO THE EDITOR)(Letter to the editor)
September 1, 2006... Dear Editor, We read with interest the recent article on etanercept and recalcitrant acrodermatitis continua of Hallopeau (ACH). (1) ACH is considered to be a particular form of palmoplantar pustular psoriasis, and is notoriously difficult...

Author's errata.(Correction notice)
September 1, 2006... In the July/August 2006 issue, in the article, "Alefacept in Combination with Ultraviolet B Phototherapy for the Treatment of Chronic Plaque Psoriasis: Results from an Open-Label, Multicenter Study," by Koo et al, the third sentence of the...

Monopolar radiofrequency facial tightening: a retrospective analysis of efficacy and safety in over 600 treatments.
September 1, 2006... Abstract Background and Objectives: Monopolar radiofrequency skin heating coupled with cryogen cooling of facial skin for skin tightening has been utilized on over 10,000 patients since 2002. In order to establish the actual rate and...

Effect of controlled volumetric tissue heating with radiofrequency on cellulite and the subcutaneous tissue of the buttocks and thighs.
September 1, 2006... Abstract Background: Regardless of diet and exercise, genetics plays an important part in creating puckering skin or dimples, which are difficult to hide at any age. The demand for a nonsurgical, noninvasive treatment of cellulite has...

Hair removal for Fitzpatrick skin types V and VI using light and heat energy technology.
September 1, 2006... Abstract Objective: To determine the safety and efficacy of a light and heat energy (LHE)-based system (SkinStaion[R] system; Radiancy Inc, Orangeburg, NY, USA) for hair removal in subjects with skin types V and VI. Methods:...

Rhytides, laxity, and photoaging treated with a combination of radiofrequency, diode laser, and pulsed light and assessed with a comprehensive grading scale.
September 1, 2006... Abstract Several classes of nonablative laser and light technologies have been developed to target laxity, rhytides, and the various aspects of photoaging. The combination of the 3 main classes of nonablative rejuvenation, infrared laser,...

Prospective clinical evaluation of 1440-NM laser delivered by microarray for treatment of photoaging and scars.
September 1, 2006... Abstract Background and Objectives: The use of thermal heating in microscopic zones is generically termed "microrejuvenation." The objective of this study was to evaluate the benefits of using a novel 1440-nm Nd: YAG laser (Affirm[TM],...

Combined 633-nm and 830-nm LED treatment of photoaging skin.
September 1, 2006... Abstract Objectives: To evaluate the clinical efficacy and ultrastructural changes in photodamaged skin after combined 633-nm and 830-nm light-emitting diode (LED) treatments. Methods: Thirty-six subjects received 9 LED treatments over...

Nonablative skin resurfacing: the role of PDT.
September 1, 2006... Abstract As demand for less invasive, highly effective cosmetic procedures grows, dermatologists must continue to explore and develop new treatment options. Nonablative skin resurfacing techniques offer an effective and noninvasive...

Photodynamic therapy: practical cosmetic applications.
September 1, 2006... Abstract Photodynamic therapy (PDT) has been used in the treatment of a variety of benign and malignant cutaneous conditions. More recently, it has been used to enhance the results of skin rejuvenation procedures. The purpose of this...

Multicenter clinical perspectives on a broadband infrared light device for skin tightening.
September 1, 2006... Abstract Modalities for skin tightening include radiofrequency (RF) energy, lasers, and combination RF and diode lasers. A new broadband infrared light device (BILD) (Titan, Cutera, Inc, Brisbane, CA) targets water to achieve dermal...

Use of antibiotics in dermatologic surgery.
September 1, 2006... Abstract When skin integrity is disrupted during a surgical procedure, its protective barrier becomes compromised and predisposes the individual to cutaneous infection. Postoperative infection remains a considerable cause of morbidity and...

Treatment considerations for inflammatory acne: clinical evidence for adapalene 0.1% in combination therapies.
September 1, 2006... Abstract Acne vulgaris is an exceptionally common, chronic, and recurring disease. It involves multiple etiological factors including follicular hyperkeratinization, increased sebum production, Propionibacterium acnes proliferation, and...

Case reports: a novel skin cream containing a mixture of human growth factors and cytokines for the treatment of adverse events associated with photodynamic therapy.
September 1, 2006... Abstract Background and Objectives: Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) is becoming a more popular dermatologic procedure. Newer protocols have virtually eliminated any associated untoward effects....

Orlando Dermatology & Aesthetic Conference.
September 1, 2006... www.orlandoderm.org JANUARY 12-15, 2007 THE PEABODY ORLANDO ORLANDO, FL ORGANIZING COMMITTED Michael Gold, MD Gold Skin Care Center Nashville, TN [ILLUSTRATION OMITTED] C. William Hanke, MD, MPH, FACP...

Case reports: development of a keratoacanthoma after topical photodynamic therapy with 5-aminolevulinic acid.
September 1, 2006... Abstract Since its FDA approval in 1999, photodynamic therapy (PDT) with topical 5-aminolevulinic acid has become an increasingly popular modality for the treatment of actinic keratosis (AKs). It is hoped that in addition to improving...

A quantitative and comprehensive grading scale for rhytides, laxity, and photoaging.(FOCUS-ON: SCALING)
September 1, 2006... Prior Global Classification Schemes In the past, grading scales were devised to assess clinical outcomes from ablative technologies, grouping the various aspects of skin aging into broad but useful classification schemes. The most widely...

Cancer risks and antibody-mediated TNF blockade.(WASHINGTON WHISPERS)
September 1, 2006... Cancer Risks and Antibody-Mediated TNF blockade Commentary on: Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in...

More evidence for cyclophosphamide in treating systemic sclerosis.(WASHINGTON WHISPERS)
September 1, 2006... More Evidence for Cyclophosphamide in Treating Systemic Sclerosis Commentary on: Cyclophosphamide versus placebo in scleroderma lung disease. Tashkin DP, et al, Scleroderma Lung Study Research Group. N Engl J Med. 2006;354:2655-66. ...

Light, ice, or cream: nonexcisional approaches to squamous cell carcinoma in situ.(WASHINGTON WHISPERS)
September 1, 2006... Light, Ice, or Cream: Nonexcisional Approaches to Squamous Cell Carcinoma in situ Commentary on: Comparison of topical methyl aminolevulinate photodynamic therapy with cryotherapy or fluorouracil for treatment of squamous cell...

FDA approves merck's cervical cancer vaccine, GARDASIL.(PIPELINE PREVIEWS)
September 1, 2006... Merck recently announced that the FDA has approved GARDASIL (Quadrivalent Human Papillomavirus [Types 6, 11, 16, 18] Recombinant Vaccine). GARDASIL is the first vaccine to prevent cervical cancers, cervical precancers, and genital warts caused...

FDA grants orphan drug designation for evaluation of CellCept in pemphigus vulgaris.(PIPELINE PREVIEWS)
September 1, 2006... Aspreva Pharmaceuticals Corporation and Roche announced that the FDA has granted an orphan drug designation for CellCept (mycophenolate mofetil) for the treatment of pemphigus vulgaris (PV). Orphan drug designations are given to treatments for...

Ranbaxy receives FDA approval to market doxycycline tablets.(PIPELINE PREVIEWS)
September 1, 2006... Ranbaxy Pharmaceuticals, Inc, recently announced that it has received FDA approval to begin manufacturing doxycycline in 50-mg, 75-mg, and 100-mg tablets. Doxycycline is indicated for a multitude of skin and skin structure infections, in...

FDA approves Orapred ODT.(PIPELINE PREVIEWS)
September 1, 2006... BioMarin Pharmaceutical, Inc, and Alliant Pharmaceuticals, Inc, recently announced that the FDA has approved Orapred ODT (prednisolone sodium phosphate orally disintegrating tablets). Orapred ODT is the first orally disintegrating tablet form...

Cynosure receives Health Canada approval to market Cynergy workstation.(PIPELINE PREVIEWS)
September 1, 2006... Cynosure, Inc, recently announced that Health Canada has granted a class III medical device license approval for Cynergy workstation with MultiPlex technology. This device has already been approved for use in the US. The Cynergy workstation is...

CollaGenex Pharmaceuticals receives FDA approval for Oracea.(PIPELINE PREVIEWS)
September 1, 2006... CollaGenex Pharmaceuticals, Inc, recently announced that the FDA has approved Oracea for the treatment of adult patients with rosacea and its characteristic inflammatory papules and pustules. Oracea is a 40-mg capsule of doxycycline, composed...

Study shows efficacy of new treatment for molluscum contagiosum.(PIPELINE PREVIEWS)
September 1, 2006... A recent double-blind, randomized, placebo-controlled trial of topical 10% potassium hydroxide solution in the treatment of molluscum contagiosum demonstrated positive results. The study enrolled 20 patients from 2 to 12 years old. Parents of...

New medication for the treatment of seborrheic dermatitis in African Americans.(PIPELINE PREVIEWS)
September 1, 2006... A recent study, published in the Journal of the American Academy of Dermatology evaluated the use of 1% pimecrolimus in the treatment of seborrheic dermatitis in African-American adults with associated hypopigmentation. This treatment obviates...

Study shows folic acid supplementation may decrease efficacy of methotrexate.(PIPELINE PREVIEWS)
September 1, 2006... A recent study evaluated folic acid (FA) supplementation during treatment of psoriasis with methotrexate (MTX). This randomized, double-blind, placebo-controlled trial enrolled 22 patients with psoriasis whose disease was stable on long-term...

Study finds calcipotriol/betamethasone dipropionate combination safe.(PIPELINE PREVIEWS)
September 1, 2006... A recent study published in the British Journal of Dermatology found the 2-compound product (Dovobet[R]/Daivobet[R]/Taclonex[R]) to be safe and effective in the treatment of psoriasis. This randomized, double-blind study enrolled 634 patients...

Imiquimod 5% cream shows efficacy in treatment of Bowen's disease.(PIPELINE PREVIEWS)
September 1, 2006... A recent randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of imiquimod 5% cream in the treatment of Bowen's disease (squamous cell carcinoma in situ). Thirty-one patients were enrolled and randomized to...

Phase II clinical trial of AN0128 for atopic dermatitis.(PIPELINE PREVIEWS)
September 1, 2006... Anacor Pharmaceuticals recently announced positive results from its phase II clinical trial of a new anti-inflammatory topical medication to be used in the treatment of atopic dermatitis (AD). AN0128 is a topical medication that inhibits the...

Phase III clinical trial of Transacin for postherpetic neuralgia.(PIPELINE PREVIEWS)
September 1, 2006... NeurogesX, Inc, recently announced completion of enrollment in its Phase 3 trial for the evaluation of an investigational drug, Transacin (NGX-4010), in the treatment of postherpetic neuralgia. Transacin is a topical, physician-administered,...

Ceftobiprole in the treatment of resistant Staphylococcus aureus skin and skin structure infections.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsored by Johnson & Johnson Pharmaceutical Research & Development, LLC. The purpose of this study is to compare the clinical cure rate of ceftobiprole medocaril versus a comparator in the treatment of patients with complicated skin and skin...

Effect of solar-simulated ultraviolet radiation on gene expression in unprotected and sunscreen-protected skin of healthy adults with Fitzpatrick skin type II.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsored by the National Cancer Institute (NCI). Genetic study to compare the effect of solar-simulated ultraviolet radiation on gene expression (protein messages produced by genes) in skin with or without sunscreen in healthy adults who have...

Comparison of telavancin and vancomycin for complicated skin and skin structure infections with a focus on methicillin-resistant Staphylococcus aureus (ATLAS 1).(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsored by Theravance. This study compares the safety and effectiveness of an investigational drug, telavancin, and an approved drug, vancomycin, for the treatment of complicated skin and skin structure infections. Condition ...

T4N5 liposomal lotion in preventing the recurrence of nonmelanoma skin cancer in patients who have undergone a kidney transplant.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsors and Collaborators: University of Alabama at Birmingham and the National Cancer Institute (NCI). This randomized phase II trial is studying how well T4N5 liposomal lotion works in preventing the recurrence of nonmelanoma skin cancer in...

Photodynamic therapy using silicon phthalocyanine 4 in treating patients with actinic keratosis, Bowen's disease, skin cancer, or stage I or stage II mycosis fungoides.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsors and Collaborators: Case Comprehensive Cancer Center and the National Cancer Institute (NCI). This phase I trial studies the side effects and best dose of photodynamic therapy using silicon phthalocyanine 4 in treating patients with...

Celecoxib in preventing skin cancer.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsors and Collaborators: Herbert Irving Comprehensive Cancer Center and the National Cancer Institute (NCI). Randomized phase II trial to study the effectiveness of celecoxib in preventing skin cancer in participants exposed to ultraviolet...

Biobank skin cancer: storing blood and protein of patients with skin cancer.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsors and Collaborators: Maastricht Radiation Oncology and University of Maastricht. The purpose of this study is to determine, by means of DNA and protein analysis, the relationship between DNA and protein profiles and a number of...

Gefitinib in treating patients undergoing surgery and/or radiation therapy for locally advanced or recurrent squamous cell skin cancer.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsors and Collaborators: M.D. Anderson Cancer Center and the National Cancer Institute (NCI). This phase II trial is studying how well gefitinib works in treating patients who are undergoing surgery and/or radiation therapy for locally...

Study evaluating sirolimus in nonmelanoma skin cancer in kidney transplant recipients.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsored by Wyeth. The purpose of this study is to determine the effect of sirolimus on the prevention of new nonmelanoma skin cancer (NMSC) in kidney transplant recipients. Condition Intervention Phase Kidney...

Tumorapa 1: efficacy of rapamycin in secondary prevention of skin cancers in kidney transplant recipients.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsored by Hospices Civils de Lyon. In a population of kidney transplant recipients having developed a first squamous cell carcinoma, the aim of the study is to assess the incidence of subsequent skin cancers over 2 years in patients who are...

The effect of Efudex treatment on photoaged skin.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsors and Collaborators: University of Michigan and Valeant Pharmaceuticals International. This research study is being done to determine if the expression of p53, a tumor suppressor gene (its activity stops the formation of tumors), is...

Study of cetuximab in squamous cell carcinoma of the skin expressing EGFR.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsors and Collaborators: Centre Hospitalier of Chartres, France. The purpose of this study is to determine whether cetuximab is effective in the treatment of locally advanced or metastatic squamous cell carcinoma of the skin expressing EGFR....

Clinical usefulness of optical skin biopsy.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsors and Collaborators: National Taiwan University Hospital. This study evaluates the clinical applications of optical skin biopsy using harmonic generation microscopy. Condition Intervention Skin Neoplasms Phase I ...

Daptomycin in the treatment of patients with renal insufficiency and complicated skin and skin structure infections.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsored by Cubist Pharmaceuticals. This is a Phase 4, randomized, open-label, multicenter, comparative study designed to further evaluate the pharmacokinetics of intravenous daptomycin and the safety and efficacy of daptomycin relative to...

Effect of bosentan on skin fibrosis in patients with systemic sclerosis.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsored by Heinrich-Heine University, Duesseldorf. The purpose of this study is to evaluate the effect of bosentan treatment on skin fibrosis and functionality in patients with systemic sclerosis. Condition Intervention ...

Computer-based continuing education for doctors in examination and counseling of patients on skin cancer or weight control.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsors and Collaborators: Rhode Island Hospital Comprehensive Cancer Center and the National Cancer Institute (NCI). This randomized clinical trial is studying how well computer-based continuing education courses work in improving doctors'...

Skin structure infections with suspected or proven MRSA.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsored by Pfizer. The purpose of this study is to determine if linezolid is superior to vancomycin in the treatment of complicated skin and soft tissue infections due to MRSA in adult subjects. Condition Intervention Phase...

Comparing skin disinfectants before labor epidural analgesia.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsored by University of British Columbia. The purpose of this study is to compare the current standard skin disinfectant solution for labor epidurales used at BC Women's Hospital to another common skin disinfectant and to the skin...

Photodynamic therapy in treating patients with skin cancer.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsors and Collaborators: Roswell Park Cancer Institute and National Cancer Institute (NCI). This randomized phase II trial is studying how well photodynamic therapy that includes aminolevulinic acid works in treating patients with skin...

Atopic dermatitis-like skin disease in pediatric heart transplant patients.(CLINICAL TRIAL REVIEW)
September 1, 2006... Sponsored by Hordinsky, Maria K., MD. The skin disease found in pediatric heart transplant patients represents an atopic dermatitis-like rash that is refractory to systemic immunomodulation. Condition Intervention ...