Journal of Drugs in Dermatology articles from October 2007

Journal of Drugs in Dermatology archives from October 2007

Letters to the editor.(Letter to the editor)
October 1, 2007... Dear JDD, We read with great interest the article by Bikowski in the July issue of the journal in which he offers a method to gain a sense of relative efficacy of acne medications that have not yet been studied in head-to-head trials. We...

Malpractice: has the rage become an inquistion?(LETTERS TO THE EDITOR)
October 1, 2007... The practice of medicine today, as it has been for generations, is based upon uncertain, changing scientific information, that may or may not be correct or predictable. In other words, academic information is forever changing, ie, what at one...

Dapsone gel 5% for the treatment of acne vulgaris: safety and efficacy of long-term (1 year) treatment.(Clinical report)
October 1, 2007... Abstract Dapsone gel 5%, a topical formulation of dapsone, was shown to deliver clinically effective doses of dapsone with minimal systemic absorption in 2 randomized, vehicle-controlled, 12-week studies of patients with acne vulgaris. A...

Novel antibacterial activity of monolaurin compared with conventional antibiotics against organisms from skin infections: an in vitro study.
October 1, 2007... Abstract Objective: A cross-sectional laboratory study to determine the in vitro sensitivity and resistance of organisms in culture isolates from skin infections and mechanisms of action of monolaurin, a coconut lauric acid derivative,...

A novel foam formulation of ketoconazole 2% for the treatment of seborrheic dermatitis on multiple body regions.(Clinical report)
October 1, 2007... Abstract Background: A novel topical foam formulation of ketoconazole has been developed for use on the scalp, body, and face. Objective: To evaluate the efficacy and safety of twice-daily treatment with ketoconazole 2% foam for...

A comparison of intense pulsed light, combination radiofrequency and intense pulsed light, and blue light in photodynamic therapy for acne vulgaris.(Clinical report)
October 1, 2007... Abstract Background: Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) is an emerging modality for the treatment of acne vulgaris. However, optimal therapeutic protocols have not been established. Objectives: To compare the...

Human growth factor and cytokine skin cream for facial skin rejuvenation as assessed by 3D in vivo optical skin imaging.(three-dimensional)(Clinical report)
October 1, 2007... Abstract Growth factors, in addition to their crucial role in cutaneous wound healing, are also beneficial for skin rejuvenation. Due to their multifunctional activities such as promoting skin cell proliferation and stimulating collagen...

Intense pulsed light versus advanced fluorescent technology pulsed light for photodamaged skin: a split-face pilot comparison.(Clinical report)
October 1, 2007... Abstract Intense pulsed light (IPL) has been a popular nonablative treatment of photodamage. A prospective, randomized, controlled, single-blinded, split-face pilot study compared the efficacy and safety of 2 multitechnology broadband...

Nipple contouring with hyaluronics postmastectomy.(CASE REPORTS)(Case study)
October 1, 2007... Abstract The lack of a naturally shaped nipple-areola complex following mastectomy presents a significant psychological hindrance for many breast cancer patients. While tattoos may improve the overall color of the reconstructed breast, the...

Treatment of lentigo maligna with imiquimod 5% cream.(CASE REPORTS)(Case study)
October 1, 2007... Abstract Lentigo maligna (LM) is an in situ melanoma that occurs in sun-damaged skin on the head and neck of elderly patients. Surgical excision is the treatment of choice for LM. However, surgical options may be limited by the location of...

Pseudoporphyria associated with voriconazole.(CASE REPORTS)(Case study)
October 1, 2007... Abstract Pseudoporphyria is a rare photosensitivity that resembles porphyria cutanea tarda clinically but lacks the biochemical derangements in porphyrin metabolism. The majority of cases are induced by ingestion of particular medications....

Exacerbation of paranoid schizophrenia in a psoriatic patient after treatment with cyclosporine a, but not with etanercept.(CASE REPORTS)(Case study)
October 1, 2007... Abstract Psoriasis may be frequently associated with psychiatric diseases. We present a 44-year-old man undergoing cyclosporine therapy for treatment of generalized plaque psoriasis which exacerbated his symptoms of paranoid schizophrenia,...

Conversion to positive tuberculosis test during etanercept treatment of psoriasis.(CASE REPORTS)(Case study)
October 1, 2007... Abstract The use of tumor necrosis factor alpha inhibitors (TNF-[alpha]) for psoriasis has raised greater awareness of tuberculosis screening. Tuberculosis can be acquired during foreign travel and also within the US by exposure to...

What's new with hyaluronic acid fillers.(AESTHETIC PRACTICE TRENDS)
October 1, 2007... Aesthetic Practice Trends is a periodic feature that will give readers updates on topics involving everyday clinical practice issues from how to run a successful dermatology practice to marketing and advertising ideas, and trends. It will also...

Gene therapy in skin disease.(NEWS, VIEWS, AND REVIEWS)
October 1, 2007... Gene therapy holds great promise for the treatment of many dermatologic diseases. (1-4) However, practical application of gene delivery has proven to be challenging. Numerous hurdles must be overcome if gene therapy is to become a viable...

Orphan Drug designation granted to VitiGam.(PIPELINE PREVIEWS)(GammaCan International, Inc.)(Brief article)
October 1, 2007... The FDA recently granted Orphan Drug designation to GammaCan International, Inc for its anticancer immunotherapy, VitiGam. The designation applies to use of VitiGam in the treatment of stage IIB to stage IV melanoma. According to the Orphan...

CLENZIderm MD for acne treatment.(PIPELINE PREVIEWS)(Brief article)
October 1, 2007... Obagi Medical Products, Inc recently presented a poster at the Summer Meeting of the American Academy of Dermatology regarding CLENZIderm MD Acne Therapeutic System. CLENZIderm MD includes a 5% benzoyl peroxide serum gel, 2% salicylic...

Cefotetan disodium for injection.(PIPELINE PREVIEWS)(Abraxis Pharmaceutical Products)(Brief article)
October 1, 2007... The FDA recently granted approval to Abraxis Pharmaceutical Products to market cefotetan disodium for injection. This medication, which is the generic equivalent of AstraZeneca's Cefotan[R], has the longest half-life of any first or second...

Positive results for CaP technology.(PIPELINE PREVIEWS)(calcium phosphate nanotechnology )(Brief article)
October 1, 2007... BioSante Pharmaceuticals recently announced positive results regarding its product, calcium phosphate nanotechnology (CaP). CaP is a potential cosmetic filler for rhytides. Preclinical data has illustrated that CaP may be as safe and last as...

MicroSpot fractional laser for skin resurfacing and rejuvenation.(PIPELINE PREVIEWS)(Lasering USA)(Brief article)
October 1, 2007... Lasering USA recently announced that its new MiXto SX[TM] C02 laser for skin resurfacing and rejuvenation has met the FDA's 510K requirements and is now available. The MiXto SX delivers fractional technology with a tightly focused beam in order...

Minocycline HCl and linezolid linked to Clostridium difficile.(PIPELINE PREVIEWS)(hydrochloride)(Brief article)
October 1, 2007... The FDA has approved a safety labeling revision for minocycline HCl (Minocin[R] made by Triax Pharmaceuticals, LLC) and linezolid (Zyvox[R] made by Pharmacia & Upjohn). The labeling revision adds a warning regarding the risk of a link between...

NouriMask[TM] available to US manufacturers.(PIPELINE PREVIEWS)(Toyo Bio-Pharma)(Brief article)
October 1, 2007... Toyo Bio-Pharma recently announced the release of NouriMask to US manufacturers. NouriMask is a coconut-based facial mask that serves as a natural delivery system for nutrient rich moisturizers, serums, and infusions. NouriMask is a...

Oral antivirals and recurrent genital herpes.(PIPELINE PREVIEWS)(Brief article)
October 1, 2007... A recent meta-analysis published in the Journal of the American Academy of Dermatology confirms that oral acyclovir, valacyclovir, and famciclovir are effective for prophylaxis against recurrent genital herpes. This study is the first...

Upcoming dermatology meetings.(Brief article)(Calendar)
October 1, 2007... Domestic 10/11-10/14 American Society for Dermatologic Surgery Sheraton Hotel & Towers, Chicago, IL info@asds.net ~ www.asds-net.org 11/8-11/11 8th Las Vegas Dermatology Seminar The Venetian, Las Vegas, NV ...

A multicenter, randomized, double-blind, parallel-group study to demonstrate the efficacy and safety of adapalene/benzoyl peroxide topical gel in subjects with acne vulgaris.(ACNE)(Brief article)
October 1, 2007... Sponsored by Galderma. The purpose of this study is to demonstrate the superiority in efficacy and assess the safety of adapalene peroxide topical gel versus adapalene topical gel, 0.1% and topical gel vehicle in the treatment of acne vulgaris...

The treatment of acne vulgaris with radiofrequency device.(ACNE)(Brief article)
October 1, 2007... Sponsored by Alma Lasers. The aim of the study is to check whether radiofrequency heating of subcutaneous and dermis will improve acne in needed patients. Condition Intervention Acne Vulgaris Device: Radio Frequency Study...

Treatment of acne scarring with subdermal manipulation.(ACNE)(Brief article)
October 1, 2007... Sponsored by Northwestern University. The primary objective of this study is to look at the efficacy of subdermal manipulation in the improvement of acne scar appearance. Condition Intervention Phase Acne...

Alefacept in patients with severe scalp alopecia areata.(ALOPECIA)(Brief article)
October 1, 2007... Sponsors and Collaborators: Maria K. Hordinsky MD and National Alopecia Areata Foundation. The purpose of this study is to examine the safety and efficacy of alefacept in the treatment of subjects with severe alopecia areata of the scalp. ...

Dose-ranging efficacy study of topical NEOSH101 to treat male pattern hair loss.(ALOPECIA)(tetrapeptide aldehyde proteasome inhibitor)(Brief article)
October 1, 2007... Sponsored by Neosil, Inc. The purpose of this study is to evaluate the safety and efficacy of 3 doses of topical NEOSH101 applied once-daily for 16 weeks in men with thinning hair in the top and center of the scalp (Norwood/Hamilton grades...

Efficacy of therapy with the spironolactone pills compared to minoxidil lotion in female pattern hair loss.(ALOPECIA)(Brief article)
October 1, 2007... Sponsored by University of British Columbia. The purpose of this study is to determine the efficacy of therapy with the antiandrogen spironolactone compared to topical minoxidil in treating female pattern hair loss. Condition ...

An evaluation of an injected filler for correction of wrinkles.(PHOTOAGING)(Brief article)
October 1, 2007... Sponsored by Northwestern University. The objective of this study is to determine whether injectable filler into wrinkles can result in safe, aesthetically pleasing, and long-lasting correction of wrinkles. Condition Intervention ...

The effect of Efudex[R] treatment on photoaged skin.(PHOTOAGING)(Brief article)
October 1, 2007... Sponsors and Collaborators: University of Michigan and Valeant Pharmaceuticals International. The researchers propose that skin improvements may be seen following a course of Efudex (5-fluorouracil), an FDA-approved topical therapy. These...

Comparison of Metvix[R] photodynamic therapy with its vehicle in the treatment of photoaged skin.(PHOTOAGING)(Brief article)
October 1, 2007... Sponsored by Galderma Metvix. The aim of the study is to assess whether Metvix PDT will be effective in correcting the effects related to photodamage and whether it will be well-tolerated. Condition Intervention Phase ...

Effects of TNF-alpha antagonism (etanercept) in patients with the metabolic syndrome and psoriasis.(PSORIASIS)(tumor necrosis factor)(Brief article)
October 1, 2007... Sponsors and Collaborators: Massachusetts General Hospital and Amgen. The purpose of this study is to determine how substances produced in the fat (inflammatory markers) relate to the risk of heart disease in people with the metabolic syndrome...

Curcuminoids for the treatment of chronic psoriasis vulgaris.(PSORIASIS)(Brief article)
October 1, 2007... Sponsored by University of Pennsylvania. The purpose of this study is to determine the safety and to estimate the efficacy of oral Curcuminoid C3 Complex[R] in patients with chronic psoriasis vulgaris. Condition Intervention ...

Fluphenazine decanoate for psoriasis.(PSORIASIS)(Brief article)
October 1, 2007... Sponsors and Collaborators: Tufts-New England Medical Center and Immune Control. The purpose of this research study is to evaluate the effectiveness and safety of fluphenazine decanoate when injected with a needle into psoriasis lesions in...

Optimization of ultraviolet radiation therapy in psoriasis.(PSORIASIS)(Brief article)
October 1, 2007... Sponsors and Collaborators: Department of Veterans Affairs and National Institutes of Health (Department of Dermatology). The purpose of this study is 1) to determine whether imiquimod or steroid pretreatment modifies ultraviolet B (UVB) laser...

T4N5 liposomal lotion in preventing the recurrence of nonmelanoma skin cancer in patients who have undergone a kidney transplant.(SKIN CANCER)(Brief article)
October 1, 2007... Sponsors and Collaborators: Lurleen Wallace Comprehensive Cancer at University of Alabama-Birmingham and National Cancer Institute (NCI). This randomized phase II trial is studying how well T4N5 liposomal lotion works in preventing the...

Optical imaging of skin cancers for margin delineation of nonmelanoma skin cancers.(SKIN CANCER)(Brief article)
October 1, 2007... Sponsors and Collaborators: MD Anderson Cancer Center and National Institute of Dental and Craniofacial Research (NIDCR). The primary objective of this exploratory laboratory study is to evaluate the ability of optical imaging technologies such...

Study evaluating sirolimus in nonmelanoma skin cancer in kidney transplant recipients.(SKIN CANCER)(Brief article)
October 1, 2007... Sponsored by Wyeth. The purpose of this study is to determine the effect of sirolimus on the prevention of new nonmelanoma skin cancer in kidney transplant recipients. Condition Intervention Phase Graft vs Host...

Photodynamic therapy in treating patients with skin cancer.(SKIN CANCER)(Brief article)
October 1, 2007... Sponsors and Collaborators: Roswell Park Cancer Institute and National Cancer Institute (NCI). This randomized phase II trial is studying how well photodynamic therapy that includes aminolevulinic acid works in treating patients with skin...

Efficacy study of antiseptic preoperative scrubs in prevention of postoperative wound infections.(SKIN INFECTION)(Brief article)
October 1, 2007... Sponsored by Baylor College of Medicine. This trial is to compare the impact of disinfecting the skin with Chloraprep[R] (2%chlorhexidine and 70% isopropyl alcohol) versus Betadine[R] on the rates of infection of clean-contaminated surgical...

Preliminary testing of new treatment for chronic leg wounds.(SKIN INFECTION)(Brief article)
October 1, 2007... Sponsors and Collaborators: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and National Gene Vector Laboratory. The long-term goal of this study is to evaluate a new approach for healing a chronic wound....

Safety and efficacy study of ICXP007 with compression bandaging for the treatment of noninfected venous leg ulcers.(SKIN INFECTION)(Brief article)
October 1, 2007... Sponsored by Intercytex. The main purpose of the study is to compare treatment of noninfected venous leg ulcers using ICXP007 combined with 4-layer compression bandaging, placebo combined with 4-layer compression bandaging, and 4-layer...

FGF-1 for topical administration for the treatment of diabetic or venous stasis ulcers.(SKIN INFECTION)(fibroblast growth factor 1)(Brief article)
October 1, 2007... Sponsored by CardioVascular BioTherapeutics, Inc. FGF-1 is being used for the treatment of patients with diabetic or venous stasis ulcers. Procedure includes topical administration of FGF-1 or placebo and evaluation of safety, pharmacokinetics,...