Journal of Drugs in Dermatology articles from October 2006

Journal of Drugs in Dermatology archives from October 2006

Taste comparison of corticosteroid suspensions.
October 1, 2006... Abstract Objective: Although numerous taste studies have compared the palatability of antibiotic suspensions, (1-6) few have compared the palatability of corticosteroid suspensions. (7,8) Therefore, we compared the taste of 8 commonly...

Successful treatment of hand and foot psoriasis with efalizumab therapy.
October 1, 2006... Abstract Hand and foot psoriasis can appear in a plaque-type or pustular-type form. Any form of psoriasis that occurs on the hands and feet can have a debilitating effect on the patient's daily functions. Here we present a case series of...

Hereditary angioedema.
October 1, 2006... Abstract Hereditary angioedema (HAE) is a rare autosomal dominant disorder caused by a CI-inhibitor deficiency. It is characterized by potentially life-threatening recurrent episodes of angioedema of the skin and mucosa. Several recent...

Topical diphenylcyclopropenone as a measure of immune competence in HIV-seropositive subjects.
October 1, 2006... Abstract Background: CD4 T cell counts are recognized as the standard method for monitoring HIV-seropositive patients and, along with viral load, are clinically important as indicators for initiating highly active antiretrovival therapy...

A novel vaccine (Zostavax) to prevent herpes zoster and postherpetic neuralgia.
October 1, 2006... Abstract Varicella-zoster virus is the causal agent of varicella and herpes zoster in humans. Herpes zoster results from reactivation of latent varicella-zoster virus (VZV) within the sensory ganglia. The incidence and severity of herpes...

Inhibition of Propionibacterium acnes by bacteriocin-like inhibitory substances (BLIS) produced by Streptococcus salivarius.
October 1, 2006... Abstract We report the in vitro inhibition of Propionibacterium acnes (P. acnes) by a bacteriocin-like inhibitory substance (BLIS-like substance) produced by Streptococcus salivarius (S. salivarius). Bacteriocins are proteinaceous...

A protocol for facial volume restoration with poly-L-lactic acid.
October 1, 2006... Abstract Poly-L-lactic acid is a biodegradable synthetic polymer used in an injectable form for subcutaneous volume restoration. Volumetric correction following subcutaneous and deep dermal injection of poly-L-lactic acid is thought to...

Oral isotretinoin for acne, adjusting treatment according to patient's response.
October 1, 2006... Abstract Background: Oral isotretinoin is an established effective therapy for acne. No published data is available on the efficacy and side effects of this drug in Iranian patients. Patients and Methods: A total of 132 acne patients...

Comparison of metformin versus rosiglitazone in patients with acanthosis nigricans: a pilot study.
October 1, 2006... Abstract Background: Acanthosis nigricans (AN) is a skin condition commonly present on the neck of obese subjects. Obesity is often accompanied by insulin resistance and/or hyperinsulinemia. Metformin and rosiglitazone are 2 pharmacologic...

Induction of lesional and circulating leukocyte apoptosis by infliximab in a patient with moderate to severe psoriasis.(CASE REPORTS)
October 1, 2006... Abstract Infliximab demonstrates high efficacy in treating psoriasis in a high proportion of patients. In this report we demonstrate induction of plaque (T cells, dendritic cells) and peripheral blood (T cells, monocytes) leukocyte...

Etanercept therapy for silicone granuloma.(CASE REPORTS)
October 1, 2006... Abstract A patient developed a typical, painful, and debilitating reaction on the thighs following injection of ostensibly medical grade "silicone" to achieve alteration of body contours. The refractory silicone granuloma responded...

An intertrigo-like eruption from pegylated liposomal doxorubicin.(CASE REPORTS)
October 1, 2006... Abstract Pegylated liposomal doxorubicin (PLD) is a chemotherapeutic agent used in the treatment of solid tumors. It has a considerably lower risk of cardiotoxicity than its parent compound, doxorubicin. PLD also has a different cutaneous...

Etanercept responsive acrodermatitis continua of Hallopeau: is a pattern developing?(CASE REPORTS)
October 1, 2006... Abstract Acrodermatitis continua of Hallopeau (ACH) is a rare disease. Little is known about its etiology or relative effectiveness of the various therapeutic approaches. However, in the literature a pattern seems to be developing on...

Successful treatment of patch type mycosis fungoides with tacrolimus ointment 0.1%.(CASE REPORTS)
October 1, 2006... Abstract Cutaneous T cell lymphomas (CTCLs) are a heterogenous group of lymphoproliferative disorders caused by clonally-derived, skin-invasive T cells. A variety of skin-directed and systemic therapies are available to treat mycosis...

Wells syndrome: an enigmatic and therapeutically challenging disease.(CASE REPORTS)
October 1, 2006... Abstract Wells syndrome, also known as eosinophilic cellulitis, is an uncommon condition whose etiology often remains a mystery. Patients present with recurrent cutaneous swellings that are often cellulitic in appearance. Histopathologic...

A role for imiquimod in the treatment of cutaneous squamous cell carcinoma in situ?(WASHINGTON WHISPERS)
October 1, 2006... Commentary on: Imiquimod 5% cream monotherapy for cutaneous squamous cell carcinoma in situ (Bowen's disease): A randomized, double-blind, placebo-controlled trial. Patel GK, et al. J Am Acad Dermatol. 2006;54:1025-1032. Summary ...

Photodynamic therapy and psoriasis.(WASHINGTON WHISPERS)(Clinical report)
October 1, 2006... Commentary on: A placebo-controlled randomized study on the clinical effectiveness, immunohistochemical changes and protoporphyrin IX accumulation in fractionated 5-aminolaevulinic acid-photodynamic therapy in patients with psoriasis....

Another potential use for imiquimod?(WASHINGTON WHISPERS)
October 1, 2006... Commentary on: Imiquimod therapy for elastosis perforans serpiginosa. Kelly SC, et al. Arch Dermatol. 2006;142:829-830. Summary The authors present a case report regarding the efficacy of imiquimod 5% cream in the treatment of...

FDA approves ZARS Pharma's S-Caine Peel.(PIPELINE PREVIEWS)
October 1, 2006... S-Caine Peel (Lidocaine and Tetracaine) 7%/7% Cream was recently approved by the FDA for use as a local topical anesthetic in adult patients. This newly approved product can be used prior to injection of dermal filler products, as well as prior...

Cefprozil Suspension approved by the FDA.(PIPELINE PREVIEWS)
October 1, 2006... Ranbaxy Pharmaceuticals, Inc, recently announced that its antibiotic, Cefprozil Suspension, has been approved for marketing as an oral suspension in the concentrations 125 mg/5 mL and 250 mg/5 mL. Cefprozil Suspension has the equivalent...

Phase III clinical study for Lipsovir.(PIPELINE PREVIEWS)(Clinical report)
October 1, 2006... Medivir recently announced the beginning of a Phase III clinical study to evaluate its product, Lipsovir (ME-609), in the prevention of labial herpes. Lipsovir is topical 5% acyclovir and 1% hydrocortisone. The multicenter study in the US and...

Phase III clinical trial for efalizumab.(PIPELINE PREVIEWS)
October 1, 2006... The results of the CLinical Experience Acquired with the Efalizumab (Raptiva) (CLEAR) trial were recently published. This multicenter, randomized, double-blind, placebo-controlled trial evaluated the safety and efficacy of efalizumab in...

Tacrolimus ointment effective in treatment of allergic contact dermatitis.(PIPELINE PREVIEWS)
October 1, 2006... A recent study evaluated 0.1% tacrolimus ointment in the treatment of nickel-induced allergic contact dermatitis (ACD). In this study, patients with nickel allergies applied nickel patches to both arms for 4 to 8 hours each day. The 0.1%...

FDA approved Xolegel Gel for the treatment of seborrheic dermatitis.(PIPELINE PREVIEWS)
October 1, 2006... Barrier Therapeutics, Inc, recently announced that the FDA has approved its product, Xolegel Gel 2% for the treatment of seborrheic dermatitis. Xolegel Gel 2% is a formulation of topical 2% ketoconazole. This formulation is a waterless gel that...

Famvir supplemental New Drug Application approved by the FDA.(PIPELINE PREVIEWS)
October 1, 2006... Novartis Pharmaceuticals Corporation recently announced that the FDA has approved a New Drug Application for its antiviral medication Famvir (famciclovir). Famvir is now approved to treat recurrent genital herpes outbreaks with one day of...

FDA expands approval for Remicade.(PIPELINE PREVIEWS)
October 1, 2006... Centocor, Inc, recently announced that the FDA has expanded its approval for Remicade (infliximab) in the treatment of psoriatic arthritis. Remicade has now been shown to inhibit progression of structural damage and to improve physical function...

Calcipotriol/betamethasone dipropionate ointment effecton PASI.(PIPELINE PREVIEWS)
October 1, 2006... A recent study evaluated the PASI response rates in patients treated with the 2-compound ointment calcipotriol/betamethasone dipropionate. Phase III trial data were compiled from 6 studies of this medication and PASI 50 and PASI 75 were...

Schools of pharmacology: retinoid update.
October 1, 2006... Abstract The most widely used retinoids include topical tretinoin (Retin-A), adapalene (Differin), topical tazarotene (Tazorac), isotretinoin (Accutane), and acitretin (Soriatane). This article will review new uses and developments in...

Treatment of Melasma with Jessner's solution versus trichloroacetic acid.(CLINICAL TRIAL REVIEW)
October 1, 2006... Sponsored by Emory University. Melasma is an acquired discoloration of the skin characterized by brown patches. Chemical peels using agents such as Jessner's solution and trichloroacetic acid (TCA) are commonly used to treat melasma. A chemical...

Cutaneous lupus erythematodes and Elidel.(CLINICAL TRIAL REVIEW)
October 1, 2006... Sponsors and Collaborators: University of Leipzig Novartis. Evaluation of the therapeutic effect of Elidel (pimecrolimus) in comparison to the corresponding vehicle in patients with chronic discoid lupus erythematosus (dLE) or subacute...

Intralesional treatment with interleukin-2 (Proleukin) in soft tissue melanoma metastases.(CLINICAL TRIAL REVIEW)
October 1, 2006... Sponsored by University Hospital Tuebingen. The intraperilesional application of interleukin-2 seems to be a safe and effective treatment of skin and soft tissue metastases in malignant melanoma. However, the management of in-transit metastases...

When to start anti-HIV drugs in children infected with HIV (The PREDICT Study).(CLINICAL TRIAL REVIEW)
October 1, 2006... Sponsors and Collaborators: National Institute of Allergy and Infectious Diseases (NIAID) and Comprehensive International Program of Research on AIDS (CIPRA). The purpose of this study is to determine when children infected with HIV should...

A study to evaluate the safety and efficacy of efalizumab in adult patients with plaque psoriasis involving the hands and/or feet.(CLINICAL TRIAL REVIEW)(Clinical report)
October 1, 2006... Sponsored by Genentech. This is a Phase IV randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of SC efalizumab in adult patients (18 years of age and older) with chronic moderate to severe plaque psoriasis...

Curcuminoids for the treatment of chronic psoriasis vulgaris.(CLINICAL TRIAL REVIEW)
October 1, 2006... Sponsored by University of Pennsylvania. Turmeric (Curcuma Longa) is member of the ginger family and is best known for its culinary use as the major component of curry powder. The volatile of oils (called curcuminoids) of the turmeric root,...

The effects of microdermabrasion on skin remodeling.(CLINICAL TRIAL REVIEW)
October 1, 2006... Sponsored by University of Michigan. This research project aims to study the effects of microdermabrasion, a technique causing minimal injury used to improve the appearance of fine lines, wrinkles, and scars. Subjects will undergo...

Noncutting laser therapy in the treatment of acne.(CLINICAL TRIAL REVIEW)
October 1, 2006... Sponsored by University of Michigan. The purpose of this research project is to study the effect of nonablative (noncutting) laser therapy, a technique that uses laser energy to try to improve the appearance of the skin. We are interested in...

The effect of Efudex treatment on photoaged skin.(CLINICAL TRIAL REVIEW)
October 1, 2006... Sponsors and collaborators: University of Michigan and Valeant Pharmaceuticals International. This research study is being done to determine if the expression of p53, a tumor suppressor gene (its activity stops the formation of tumors), is...

Ultraviolet (UVA) light therapy in the treatment of inflammatory skin conditions.(CLINICAL TRIAL REVIEW)
October 1, 2006... Sponsored by University of Michigan. The purpose of this investigation is to study the effectiveness of longer wavelength UVA1 (340-400 nm) or shorter wavelength ultraviolet B [UVB] (290-320 nm) irradiation in the treatment of inflammatory skin...

Etanercept for treatment of hidradenitis.(CLINICAL TRIAL REVIEW)
October 1, 2006... Sponsored by University of Pennsylvania. The purpose of this study is to determine whether etanercept is safe and effective for the treatment of hidradenitis. Another purpose of this study is to determine the impact of etanercept treatment of...

Study of mycobacterial infections.(CLINICAL TRIAL REVIEW)
October 1, 2006... Sponsored by National Institute of Allergy and Infectious Diseases (NIAID). This study will examine the symptoms, course of disease, and treatment of nontuberculous mycobacterial (NTM) infections, as well as the genetics involved in these...

Study to determine if tissue scored with a scalpel results in any noticeable marks.(CLINICAL TRIAL REVIEW)
October 1, 2006... Sponsored by University of California, Davis. This study is to determine if there is a noticeable difference in outcome between patients who have their tissue lightly scored with a scalpel or marked with a surgical marking pen. Condition...

Efficacy and safety of calcipotriol plus betamethasone dipropionate gel in psoriasis vulgaris.(CLINICAL TRIAL REVIEW)
October 1, 2006... Sponsored by LEO Pharma. The objective of the study is to compare the use of calcipotriol plus betamethasone dipropionate gel with betamethasone dipropionate in the gel vehicle, calcipotriol in the gel vehicle and the gel vehicle alone when...

Efficacy and safety of itraconazole tablets versus itraconazole capsules versus placebo for the treatment of onychomycosis of the toenail.(CLINICAL TRIAL REVIEW)
October 1, 2006... Sponsored by Barrier Therapeutics. Onychomycosis is a common condition accounting for approximately half of all nail disorders. It is most commonly caused by dermatophytes. Itraconazole has been approved for the treatment of onychomycosis in...

Efficacy of therapy with the spironolactone pills compared to minoxidil lotion in female pattern hair loss.(CLINICAL TRIAL REVIEW)
October 1, 2006... Sponsored by University of British Columbia. This study compares the efficacy of therapy with the anti-androgen spironolactone compared to topical minoxidil in female pattern hair loss. Condition Intervention Phase ...

Comparison of excision versus punch incision in the treatment of epidermal cysts.(CLINICAL TRIAL REVIEW)
October 1, 2006... Sponsored by Emory University. The purpose of this trial is to compare 2 standards of care treatments for removing epidermal cysts. Surgical excision removes the entire cyst but requires a larger hole in the skin. A punch incision makes a...

Collecting tissue samples from patients with melanocytic nevi or pigmented lesions.(CLINICAL TRIAL REVIEW)
October 1, 2006... Sponsored by National Cancer Institute (NCI). This clinical trial is collecting and storing tissue samples to study in the laboratory from patients with melanocytic nevi or pigmented lesions. Condition Intervention ...

Elidel in patients with atopic dermatitis.(CLINICAL TRIAL REVIEW)
October 1, 2006... Sponsored by Dresden University of Technology. Emollients and Elidel have both shown to be effective to treat atopic dermatitis. The research question is, whether the effective component (Elidel) is better than the emollient to improve the skin...

The impact of treating Staphylococcus Aureus infection and colonization on the clinical severity of atopic dermatitis.(CLINICAL TRIAL REVIEW)(Clinical report)
October 1, 2006... Sponsors and Collaborators: Children's Memorial Hospital, Society for Pediatric Dermatology, and Johnson & Johnson. We would like to perform a randomized investigator-blinded placebo-controlled study of children aged 6 months to 17 years with...